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Virus-helminth coinfection reveals a microbiota-independent mechanism of immunomodulation

Overview of attention for article published in Science, July 2014
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • Good Attention Score compared to outputs of the same age and source (78th percentile)

Mentioned by

news
2 news outlets
blogs
1 blog
twitter
53 X users
patent
1 patent
facebook
1 Facebook page
f1000
1 research highlight platform

Citations

dimensions_citation
230 Dimensions

Readers on

mendeley
361 Mendeley
citeulike
2 CiteULike
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Title
Virus-helminth coinfection reveals a microbiota-independent mechanism of immunomodulation
Published in
Science, July 2014
DOI 10.1126/science.1256942
Pubmed ID
Authors

Lisa C Osborne, Laurel A Monticelli, Timothy J Nice, Tara E Sutherland, Mark C Siracusa, Matthew R Hepworth, Vesselin T Tomov, Dmytro Kobuley, Sara V Tran, Kyle Bittinger, Aubrey G Bailey, Alice L Laughlin, Jean-Luc Boucher, E John Wherry, Frederic D Bushman, Judith E Allen, Herbert W Virgin, David Artis

Abstract

The mammalian intestine is colonized by beneficial commensal bacteria and is a site of infection by pathogens, including helminth parasites. Helminths induce potent immunomodulatory effects, but whether these effects are mediated by direct regulation of host immunity or indirectly through eliciting changes in the microbiota is unknown. We tested this in the context of virus-helminth coinfection. Helminth coinfection resulted in impaired antiviral immunity and was associated with changes in the microbiota and STAT6-dependent helminth-induced alternative activation of macrophages. Notably, helminth-induced impairment of antiviral immunity was evident in germ-free mice, but neutralization of Ym1, a chitinase-like molecule that is associated with alternatively activated macrophages, could partially restore antiviral immunity. These data indicate that helminth-induced immunomodulation occurs independently of changes in the microbiota but is dependent on Ym1.

X Demographics

X Demographics

The data shown below were collected from the profiles of 53 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 361 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 7 2%
United Kingdom 4 1%
Korea, Republic of 2 <1%
Sweden 1 <1%
Finland 1 <1%
Denmark 1 <1%
Brazil 1 <1%
Thailand 1 <1%
Netherlands 1 <1%
Other 0 0%
Unknown 342 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 101 28%
Researcher 82 23%
Student > Master 28 8%
Student > Bachelor 25 7%
Student > Doctoral Student 24 7%
Other 64 18%
Unknown 37 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 119 33%
Immunology and Microbiology 89 25%
Medicine and Dentistry 42 12%
Biochemistry, Genetics and Molecular Biology 32 9%
Veterinary Science and Veterinary Medicine 8 2%
Other 28 8%
Unknown 43 12%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 61. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 August 2023.
All research outputs
#702,303
of 25,373,627 outputs
Outputs from Science
#15,119
of 82,915 outputs
Outputs of similar age
#6,306
of 227,501 outputs
Outputs of similar age from Science
#192
of 912 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 82,915 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 65.7. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 227,501 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 912 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.