Title |
The Neutrophil NLRC4 Inflammasome Selectively Promotes IL-1β Maturation without Pyroptosis during Acute Salmonella Challenge
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Published in |
Cell Reports, July 2014
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DOI | 10.1016/j.celrep.2014.06.028 |
Pubmed ID | |
Authors |
Kaiwen W. Chen, Christina J. Groß, Flor Vásquez Sotomayor, Katryn J. Stacey, Jurg Tschopp, Matthew J. Sweet, Kate Schroder |
Abstract |
The macrophage NLRC4 inflammasome drives potent innate immune responses against Salmonella by eliciting caspase-1-dependent proinflammatory cytokine production (e.g., interleukin-1β [IL-1β]) and pyroptotic cell death. However, the potential contribution of other cell types to inflammasome-mediated host defense against Salmonella was unclear. Here, we demonstrate that neutrophils, typically viewed as cellular targets of IL-1β, themselves activate the NLRC4 inflammasome during acute Salmonella infection and are a major cell compartment for IL-1β production during acute peritoneal challenge in vivo. Importantly, unlike macrophages, neutrophils do not undergo pyroptosis upon NLRC4 inflammasome activation. The resistance of neutrophils to pyroptotic death is unique among inflammasome-signaling cells so far described and allows neutrophils to sustain IL-1β production at a site of infection without compromising the crucial inflammasome-independent antimicrobial effector functions that would be lost if neutrophils rapidly lysed upon caspase-1 activation. Inflammasome pathway modification in neutrophils thus maximizes host proinflammatory and antimicrobial responses during pathogen challenge. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Australia | 2 | 33% |
Germany | 1 | 17% |
United Kingdom | 1 | 17% |
Unknown | 2 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 3 | 50% |
Members of the public | 2 | 33% |
Practitioners (doctors, other healthcare professionals) | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | <1% |
Australia | 1 | <1% |
Brazil | 1 | <1% |
Spain | 1 | <1% |
United States | 1 | <1% |
Unknown | 284 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 81 | 28% |
Researcher | 44 | 15% |
Student > Master | 30 | 10% |
Student > Bachelor | 30 | 10% |
Student > Doctoral Student | 20 | 7% |
Other | 40 | 14% |
Unknown | 44 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 79 | 27% |
Immunology and Microbiology | 64 | 22% |
Biochemistry, Genetics and Molecular Biology | 47 | 16% |
Medicine and Dentistry | 29 | 10% |
Neuroscience | 3 | 1% |
Other | 17 | 6% |
Unknown | 50 | 17% |