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Glial Cells in Health and Disease of the CNS

Overview of attention for book
Cover of 'Glial Cells in Health and Disease of the CNS'

Table of Contents

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    Book Overview
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    Chapter 1 Glial Cells and Integrity of the Nervous System
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    Chapter 2 NG2-glia, More Than Progenitor Cells
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    Chapter 3 Pharmacological Tools to Study the Role of Astrocytes in Neural Network Functions
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    Chapter 4 Microglia Function in the Normal Brain
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    Chapter 5 Physiological Functions of Glial Cell Hemichannels
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    Chapter 6 Role of Astrocytes in Central Respiratory Chemoreception
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    Chapter 7 Purine Signaling and Microglial Wrapping
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    Chapter 8 Oligodendrocytes: Functioning in a Delicate Balance Between High Metabolic Requirements and Oxidative Damage
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    Chapter 9 Schwann Cell and Axon: An Interlaced Unit—From Action Potential to Phenotype Expression
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    Chapter 10 Glial Cells in Health and Disease of the CNS
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    Chapter 11 Astrocyte Dysfunction in Developmental Neurometabolic Diseases
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    Chapter 12 Microglia in Cancer: For Good or for Bad?
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    Chapter 13 Peripheral Inflammation and Demyelinating Diseases
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    Chapter 14 Regulation of Oligodendrocyte Differentiation and Myelination by Nuclear Receptors: Role in Neurodegenerative Disorders
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    Chapter 15 The Role of Galectin-3: From Oligodendroglial Differentiation and Myelination to Demyelination and Remyelination Processes in a Cuprizone-Induced Demyelination Model
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    Chapter 16 Prenatal Systemic Hypoxia-Ischemia and Oligodendroglia Loss in Cerebellum
Attention for Chapter 9: Schwann Cell and Axon: An Interlaced Unit—From Action Potential to Phenotype Expression
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Chapter title
Schwann Cell and Axon: An Interlaced Unit—From Action Potential to Phenotype Expression
Chapter number 9
Book title
Glial Cells in Health and Disease of the CNS
Published in
Advances in experimental medicine and biology, January 2016
DOI 10.1007/978-3-319-40764-7_9
Pubmed ID
Book ISBNs
978-3-31-940762-3, 978-3-31-940764-7
Authors

Felipe A. Court, Jaime Alvarez, Court, Felipe A., Alvarez, Jaime

Abstract

Here we propose a model of a peripheral axon with a great deal of autonomy from its cell body-the autonomous axon-but with a substantial dependence on its ensheathing Schwann cell (SC), the axon-SC unit. We review evidence in several fields and show that (i) axons can extend sprouts and grow without the concurrence of the cell body, but regulated by SCs; (ii) axons synthesize their proteins assisted by SCs that supply them with ribosomes and, probably, with mRNAs by way of exosomes; (iii) the molecular organization of the axoplasm, i.e., its phenotype, is regulated by the SC, as illustrated by the axonal microtubular content, which is down-regulated by the SC; and (iv) the axon has a program for self-destruction that is boosted by the SC. The main novelty of this model axon-SC unit is that it breaks with the notion that all proteins of the nerve cell are specified by its own nucleus. The notion of a collaborative specification of the axoplasm by more than one nucleus, which we present here, opens a new dimension in the understanding of the nervous system in health and disease and is also a frame of reference to understand other tissues or cell associations.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 6%
Unknown 32 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 24%
Student > Master 4 12%
Researcher 3 9%
Student > Doctoral Student 2 6%
Student > Bachelor 2 6%
Other 4 12%
Unknown 11 32%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 6 18%
Medicine and Dentistry 5 15%
Agricultural and Biological Sciences 4 12%
Neuroscience 3 9%
Nursing and Health Professions 1 3%
Other 4 12%
Unknown 11 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 September 2017.
All research outputs
#15,478,452
of 23,001,641 outputs
Outputs from Advances in experimental medicine and biology
#2,515
of 4,961 outputs
Outputs of similar age
#232,133
of 394,604 outputs
Outputs of similar age from Advances in experimental medicine and biology
#221
of 444 outputs
Altmetric has tracked 23,001,641 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,961 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 394,604 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 444 others from the same source and published within six weeks on either side of this one. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.