| Chapter title |
Astrocyte Dysfunction in Developmental Neurometabolic Diseases
|
|---|---|
| Chapter number | 11 |
| Book title |
Glial Cells in Health and Disease of the CNS
|
| Published in |
Advances in experimental medicine and biology, January 2016
|
| DOI | 10.1007/978-3-319-40764-7_11 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-940762-3, 978-3-31-940764-7
|
| Authors |
Silvia Olivera-Bravo, Eugenia Isasi, Anabel Fernández, Gabriela Casanova, Juan Carlos Rosillo, Luigi Barbeito, Olivera-Bravo, Silvia, Isasi, Eugenia, Fernández, Anabel, Casanova, Gabriela, Rosillo, Juan Carlos, Barbeito, Luigi |
| Abstract |
Astrocytes play crucial roles in maintaining brain homeostasis and in orchestrating neural development, all through tightly coordinated steps that cooperate to maintain the balance needed for normal development. Here, we review the alterations in astrocyte functions that contribute to a variety of developmental neurometabolic disorders and provide additional data on the predominant role of astrocyte dysfunction in the neurometabolic neurodegenerative disease glutaric acidemia type I. Finally, we describe some of the therapeutical approaches directed to neurometabolic diseases and discuss if astrocytes can be possible therapeutic targets for treating these disorders. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 25 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 5 | 20% |
| Researcher | 4 | 16% |
| Other | 3 | 12% |
| Student > Bachelor | 3 | 12% |
| Professor > Associate Professor | 2 | 8% |
| Other | 3 | 12% |
| Unknown | 5 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 7 | 28% |
| Biochemistry, Genetics and Molecular Biology | 3 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 8% |
| Veterinary Science and Veterinary Medicine | 1 | 4% |
| Agricultural and Biological Sciences | 1 | 4% |
| Other | 3 | 12% |
| Unknown | 8 | 32% |