| Title |
Molecular mechanism of SCARB2-mediated attachment and uncoating of EV71
|
|---|---|
| Published in |
Protein & Cell, July 2014
|
| DOI | 10.1007/s13238-014-0087-3 |
| Pubmed ID | |
| Authors |
Minghao Dang, Xiangxi Wang, Quan Wang, Yaxin Wang, Jianping Lin, Yuna Sun, Xuemei Li, Liguo Zhang, Zhiyong Lou, Junzhi Wang, Zihe Rao |
| Abstract |
Unlike the well-established picture for the entry of enveloped viruses, the mechanism of cellular entry of non-enveloped eukaryotic viruses remains largely mysterious. Picornaviruses are representative models for such viruses, and initiate this entry process by their functional receptors. Here we present the structural and functional studies of SCARB2, a functional receptor of the important human enterovirus 71 (EV71). SCARB2 is responsible for attachment as well as uncoating of EV71. Differences in the structures of SCARB2 under neutral and acidic conditions reveal that SCARB2 undergoes a pivotal pH-dependent conformational change which opens a lipid-transfer tunnel to mediate the expulsion of a hydrophobic pocket factor from the virion, a pre-requisite for uncoating. We have also identified the key residues essential for attachment to SCARB2, identifying the canyon region of EV71 as mediating the receptor interaction. Together these results provide a clear understanding of cellular attachment and initiation of uncoating for enteroviruses. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 74 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 19 | 26% |
| Student > Bachelor | 17 | 23% |
| Student > Master | 11 | 15% |
| Researcher | 10 | 14% |
| Student > Doctoral Student | 2 | 3% |
| Other | 4 | 5% |
| Unknown | 11 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 23 | 31% |
| Agricultural and Biological Sciences | 13 | 18% |
| Immunology and Microbiology | 8 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 7% |
| Medicine and Dentistry | 5 | 7% |
| Other | 7 | 9% |
| Unknown | 13 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 37. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 July 2014.
All research outputs
#934,260
of 22,758,963 outputs
Outputs from Protein & Cell
#32
of 739 outputs
Outputs of similar age
#9,944
of 227,684 outputs
Outputs of similar age from Protein & Cell
#1
of 17 outputs
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So far Altmetric has tracked 739 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.4. This one has done particularly well, scoring higher than 95% of its peers.
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We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.