| Title |
Genetic variation in the G72 gene is associated with increased frontotemporal fiber tract integrity
|
|---|---|
| Published in |
European Archives of Psychiatry and Clinical Neuroscience, July 2014
|
| DOI | 10.1007/s00406-014-0516-6 |
| Pubmed ID | |
| Authors |
Thomas Nickl-Jockschat, Tony Stöcker, Axel Krug, Valentin Markov, Ivan I. Maximov, Ruiwang Huang, Frank Schneider, Ute Habel, Simon B. Eickhoff, Klaus Zerres, Markus M. Nöthen, Marcella Rietschel, N. Jon Shah, Jens Treutlein, Tilo Kircher |
| Abstract |
G72 (syn. DAOA, D-amino acid oxidase activator) is a susceptibility gene for both schizophrenia and bipolar disorder. Diffusion tensor imaging studies hint at changes in fiber tract integrity in both disorders. We aimed to investigate whether a G72 susceptibility haplotype causes changes in fiber tract integrity in young healthy subjects. We compared fractional anisotropy in 47 subjects that were either homozygous for the M23/M24 risk haplotype (n = 20) or homozygous for M23(rs3918342)/M24(rs1421292) wild type (n = 27) using diffusion tensor imaging with 3 T. Tract-based spatial statistics, a method especially developed for diffusion data analysis, was used to delineate the major fiber tracts. We found clusters of increased FA values in homozygous risk haplotype carriers in the right periinsular region and in the right inferior parietal lobe (IPL). We did not find clusters indicating decreased FA values. The insula and the IPL have been implicated in both schizophrenia and bipolar pathophysiology. Increased FA values might reflect changes in dendritic morphology as previously described by in vitro studies. These findings further corroborate the hypothesis that a shared gene pool between schizophrenia and bipolar disorder might lead to neuroanatomic changes that confer an unspecific vulnerability for both disorders. |
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 43 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 19% |
| Researcher | 6 | 14% |
| Student > Master | 4 | 9% |
| Professor | 4 | 9% |
| Student > Bachelor | 2 | 5% |
| Other | 4 | 9% |
| Unknown | 15 | 35% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 7 | 16% |
| Medicine and Dentistry | 5 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 7% |
| Agricultural and Biological Sciences | 2 | 5% |
| Biochemistry, Genetics and Molecular Biology | 2 | 5% |
| Other | 3 | 7% |
| Unknown | 21 | 49% |
Attention Score in Context
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#19,221,261
of 23,815,455 outputs
Outputs from European Archives of Psychiatry and Clinical Neuroscience
#987
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#148,322
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Outputs of similar age from European Archives of Psychiatry and Clinical Neuroscience
#9
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