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Decreased Endothelial Nitric Oxide Bioavailability, Impaired Microvascular Function, and Increased Tissue Oxygen Consumption in Children with Falciparum Malaria

Overview of attention for article published in Journal of Infectious Diseases, May 2014
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Title
Decreased Endothelial Nitric Oxide Bioavailability, Impaired Microvascular Function, and Increased Tissue Oxygen Consumption in Children with Falciparum Malaria
Published in
Journal of Infectious Diseases, May 2014
DOI 10.1093/infdis/jiu308
Pubmed ID
Authors

Tsin W. Yeo, Daniel A. Lampah, Enny Kenangalem, Emiliana Tjitra, J. Brice Weinberg, Donald L. Granger, Ric N. Price, Nicholas M. Anstey

Abstract

Endothelial nitric oxide (NO) bioavailability, microvascular function, and host oxygen consumption have not been assessed in pediatric malaria. We measured NO-dependent endothelial function by using peripheral artery tonometry to determine the reactive hyperemia index (RHI), and microvascular function and oxygen consumption (VO2) using near infrared resonance spectroscopy in 13 Indonesian children with severe falciparum malaria and 15 with moderately severe falciparum malaria. Compared with 19 controls, children with severe malaria and those with moderately severe malaria had lower RHIs (P = .03); 12% and 8% lower microvascular function, respectively (P = .03); and 29% and 25% higher VO2, respectively. RHIs correlated with microvascular function in all children with malaria (P < .001) and all with severe malaria (P < .001). Children with malaria have decreased endothelial and microvascular function and increased oxygen consumption, likely contributing to the pathogenesis of the disease.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 2%
Denmark 1 2%
Canada 1 2%
Brazil 1 2%
Unknown 54 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 22%
Researcher 8 14%
Student > Master 8 14%
Student > Bachelor 5 9%
Lecturer 2 3%
Other 6 10%
Unknown 16 28%
Readers by discipline Count As %
Medicine and Dentistry 16 28%
Biochemistry, Genetics and Molecular Biology 5 9%
Agricultural and Biological Sciences 5 9%
Immunology and Microbiology 5 9%
Computer Science 3 5%
Other 8 14%
Unknown 16 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 December 2014.
All research outputs
#17,285,036
of 25,373,627 outputs
Outputs from Journal of Infectious Diseases
#12,623
of 14,794 outputs
Outputs of similar age
#144,646
of 240,670 outputs
Outputs of similar age from Journal of Infectious Diseases
#67
of 103 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 14,794 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.4. This one is in the 9th percentile – i.e., 9% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 240,670 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 103 others from the same source and published within six weeks on either side of this one. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.