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Mendeley readers
Attention Score in Context
| Title |
Targeting Cancer-Derived Adenosine:New Therapeutic Approaches
|
|---|---|
| Published in |
Cancer Discovery, August 2014
|
| DOI | 10.1158/2159-8290.cd-14-0341 |
| Pubmed ID | |
| Authors |
Arabella Young, Deepak Mittal, John Stagg, Mark J. Smyth |
| Abstract |
CD73 generation of immunosuppressive adenosine within the hypoxic tumor microenvironment causes dysregulation of immune cell infiltrates, resulting in tumor progression, metastases, and poor disease outcomes. Therapies targeted toward the adenosinergic pathway, such as antibodies targeting CD73 and CD39, have proven efficacy in mouse tumor models; however, humanized versions are only in preliminary development. In contrast, A2A adenosine receptor antagonists have progressed to late-stage clinical trials in Parkinson disease, yet evidence of their role in oncology is limited. This review will compare the merits and challenges of these therapeutic approaches, identifying tumor indications and combinations that may be fruitful as they progress to the clinic. |
Mendeley readers
The data shown below were compiled from readership statistics for 273 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 2 | <1% |
| Denmark | 1 | <1% |
| Germany | 1 | <1% |
| Italy | 1 | <1% |
| Unknown | 268 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 70 | 26% |
| Student > Ph. D. Student | 36 | 13% |
| Student > Master | 29 | 11% |
| Student > Bachelor | 20 | 7% |
| Professor | 18 | 7% |
| Other | 48 | 18% |
| Unknown | 52 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 52 | 19% |
| Medicine and Dentistry | 47 | 17% |
| Biochemistry, Genetics and Molecular Biology | 37 | 14% |
| Immunology and Microbiology | 31 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 17 | 6% |
| Other | 27 | 10% |
| Unknown | 62 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 March 2024.
All research outputs
#1,868,570
of 23,577,654 outputs
Outputs from Cancer Discovery
#830
of 3,795 outputs
Outputs of similar age
#19,562
of 231,547 outputs
Outputs of similar age from Cancer Discovery
#8
of 60 outputs
Altmetric has tracked 23,577,654 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,795 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.7. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 231,547 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 60 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.