You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
L1 Retrotransposons and Somatic Mosaicism in the Brain
|
|---|---|
| Published in |
Annual Review of Genetics, July 2014
|
| DOI | 10.1146/annurev-genet-120213-092412 |
| Pubmed ID | |
| Authors |
Sandra R. Richardson, Santiago Morell, Geoffrey J. Faulkner |
| Abstract |
Long interspersed element 1 (LINE-1 or L1) retrotransposons have generated one-third of the human genome, and their ongoing mobility is a source of inter- and intraindividual genetic diversity. Although retrotransposition in metazoans has long been considered a germline phenomenon, recent experiments using cultured cells, animal models, and human tissues have revealed extensive L1 mobilization in rodent and human neurons, as well as mobile element activity in the Drosophila brain. In this review, we evaluate the available evidence for L1 retrotransposition in the brain and discuss mechanisms that may regulate neuronal retrotransposition in vivo. We compare experimental strategies used to map de novo somatic retrotransposition events and present the optimal criteria to identify a somatic L1 insertion. Finally, we discuss the unresolved impact of L1-mediated somatic mosaicism upon normal neurobiology, as well as its potential to drive neurological disease. Expected final online publication date for the Annual Review of Genetics Volume 48 is November 23, 2014. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 259 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 2 | <1% |
| Canada | 2 | <1% |
| United States | 2 | <1% |
| Sweden | 1 | <1% |
| Japan | 1 | <1% |
| France | 1 | <1% |
| Unknown | 250 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 54 | 21% |
| Researcher | 54 | 21% |
| Student > Bachelor | 28 | 11% |
| Student > Master | 26 | 10% |
| Professor | 18 | 7% |
| Other | 47 | 18% |
| Unknown | 32 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 86 | 33% |
| Biochemistry, Genetics and Molecular Biology | 71 | 27% |
| Neuroscience | 25 | 10% |
| Medicine and Dentistry | 10 | 4% |
| Computer Science | 6 | 2% |
| Other | 22 | 8% |
| Unknown | 39 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 October 2015.
All research outputs
#2,811,444
of 25,374,917 outputs
Outputs from Annual Review of Genetics
#154
of 783 outputs
Outputs of similar age
#27,504
of 241,474 outputs
Outputs of similar age from Annual Review of Genetics
#1
of 6 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 783 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.7. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 241,474 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them