| Title |
Molecular understanding of aminoglycoside action and resistance
|
|---|---|
| Published in |
Applied Microbiology and Biotechnology, January 2006
|
| DOI | 10.1007/s00253-005-0279-0 |
| Pubmed ID | |
| Authors |
S. Jana, J. K. Deb |
| Abstract |
Aminoglycosides are potent bactericidal antibiotics targeting the bacterial ribosome, where they bind to the A-site and disrupt protein synthesis. They are particularly active against aerobic, Gram-negative bacteria and act synergistically against certain Gram-positive organisms. Aminoglycosides are used in the treatment of severe infections of the abdomen and urinary tract, bacteremia, and endocarditis. They are also used for prophylaxis, especially against endocarditis. Bacterial resistance to aminoglycosides continues to escalate and is widely recognized as a serious health threat. This might be the reason for the interest in understanding the mechanisms of resistance. It is now clear that the resistance occurs by different mechanisms such as prevention of drug entry, active extrusion of drugs, alteration of the drug target (mutational modification of 16S rRNA and mutational modification of ribosomal proteins), and enzymatic inactivation through the expression of enzymes, which covalently modify these antibiotics. Enzymatic inactivation is normally due to acetyltransferases, nucleotidyltransferases, and phosphotransferases. In this review, we focus on the recent concept of molecular understanding of aminoglycoside action and resistance. |
Mendeley readers
The data shown below were compiled from readership statistics for 358 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 3 | <1% |
| United States | 2 | <1% |
| Germany | 1 | <1% |
| Malaysia | 1 | <1% |
| Brazil | 1 | <1% |
| United Kingdom | 1 | <1% |
| Israel | 1 | <1% |
| Portugal | 1 | <1% |
| Belgium | 1 | <1% |
| Other | 3 | <1% |
| Unknown | 343 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 80 | 22% |
| Student > Master | 57 | 16% |
| Researcher | 40 | 11% |
| Student > Bachelor | 39 | 11% |
| Student > Doctoral Student | 18 | 5% |
| Other | 51 | 14% |
| Unknown | 73 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 82 | 23% |
| Biochemistry, Genetics and Molecular Biology | 43 | 12% |
| Chemistry | 42 | 12% |
| Medicine and Dentistry | 37 | 10% |
| Immunology and Microbiology | 24 | 7% |
| Other | 46 | 13% |
| Unknown | 84 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 September 2021.
All research outputs
#2,811,052
of 25,373,627 outputs
Outputs from Applied Microbiology and Biotechnology
#274
of 8,290 outputs
Outputs of similar age
#8,670
of 172,808 outputs
Outputs of similar age from Applied Microbiology and Biotechnology
#2
of 41 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,290 research outputs from this source. They receive a mean Attention Score of 4.4. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 172,808 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.