Title |
Clinicopathologic Features and Treatment Outcomes in Cronkhite–Canada Syndrome: Support for Autoimmunity
|
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Published in |
Digestive Diseases and Sciences, September 2011
|
DOI | 10.1007/s10620-011-1874-9 |
Pubmed ID | |
Authors |
Seth Sweetser, David A. Ahlquist, Neal K. Osborn, Schuyler O. Sanderson, Thomas C. Smyrk, Suresh T. Chari, Lisa A. Boardman |
Abstract |
Cronkhite-Canada syndrome (CCS) is a noninherited condition, associated with high morbidity, and characterized by gastrointestinal hamartomatous polyposis, alopecia, onychodystrophy, hyperpigmentation, and diarrhea. All features may respond to immunosuppressive therapy, but little is known about the etiology. An autoimmune origin has been suggested but not proved. From a retrospectively selected cohort, we evaluated clinicopathologic features, including immunostaining for IgG4 (an antibody associated with autoimmunity), and therapeutic outcomes in a cohort of CCS patients to provide further insights into this disease. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 37 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Other | 5 | 14% |
Researcher | 5 | 14% |
Student > Ph. D. Student | 3 | 8% |
Student > Master | 3 | 8% |
Lecturer > Senior Lecturer | 2 | 5% |
Other | 7 | 19% |
Unknown | 12 | 32% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 20 | 54% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
Neuroscience | 1 | 3% |
Social Sciences | 1 | 3% |
Unknown | 14 | 38% |