Title |
A novel clinical entity, IgG4-related disease (IgG4RD): general concept and details
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Published in |
Modern Rheumatology, September 2011
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DOI | 10.1007/s10165-011-0508-6 |
Pubmed ID | |
Authors |
Hisanori Umehara, Kazuichi Okazaki, Yasufumi Masaki, Mitsuhiro Kawano, Motohisa Yamamoto, Takako Saeki, Shoko Matsui, Takayuki Sumida, Tsuneyo Mimori, Yoshiya Tanaka, Kazuo Tsubota, Tadashi Yoshino, Shigeyuki Kawa, Ritsuro Suzuki, Tsutomu Takegami, Naohisa Tomosugi, Nozomu Kurose, Yasuhito Ishigaki, Atsushi Azumi, Masaru Kojima, Shigeo Nakamura, Dai Inoue, The Research Program for Intractable Disease by Ministry of Health, Labor and Welfare (MHLW) Japan G4 team |
Abstract |
IgG4-related disease (IgG4RD) is a novel clinical disease entity characterized by elevated serum IgG4 concentration and tumefaction or tissue infiltration by IgG4-positive plasma cells. IgG4RD may be present in a certain proportion of patients with a wide variety of diseases, including Mikulicz's disease, autoimmune pancreatitis, hypophysitis, Riedel thyroiditis, interstitial pneumonitis, interstitial nephritis, prostatitis, lymphadenopathy, retroperitoneal fibrosis, inflammatory aortic aneurysm, and inflammatory pseudotumor. Although IgG4RD forms a distinct, clinically independent disease category and is attracting strong attention as a new clinical entity, many questions and problems still remain to be elucidated, including its pathogenesis, the establishment of diagnostic criteria, and the role of IgG4. Here we describe the concept of IgG4RD and up-to-date information on this emerging disease entity. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Portugal | 1 | <1% |
Germany | 1 | <1% |
Italy | 1 | <1% |
Mexico | 1 | <1% |
Japan | 1 | <1% |
Unknown | 259 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 49 | 19% |
Researcher | 35 | 13% |
Student > Postgraduate | 25 | 9% |
Student > Ph. D. Student | 21 | 8% |
Student > Master | 21 | 8% |
Other | 63 | 24% |
Unknown | 50 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 151 | 57% |
Agricultural and Biological Sciences | 15 | 6% |
Immunology and Microbiology | 12 | 5% |
Neuroscience | 7 | 3% |
Biochemistry, Genetics and Molecular Biology | 5 | 2% |
Other | 15 | 6% |
Unknown | 59 | 22% |