| Title |
Automated mass spectrometry imaging with a matrix-assisted laser desorption ionization time-of-flight instrument
|
|---|---|
| Published in |
Journal of the American Society for Mass Spectrometry, January 1999
|
| DOI | 10.1016/s1044-0305(98)00126-3 |
| Pubmed ID | |
| Authors |
Markus Stoeckli, Terry B. Farmer, Richard M. Caprioli |
| Abstract |
The automated use of a matrix-assisted laser desorption ionization (MALDI) mass spectrometer (MS) is described for image analysis of samples through implementation of new software for instrument control, data acquisition, and data analysis. The software permits automated acquisition of MS MALDI spectra to form an ordered data array and contains display features to provide images at one or more mass-to-charge ratio values. The technique can be used to scan tissue samples, blotted samples, gels, or other sample surfaces where the image analysis of that sample is required. The program achieves a time of typically 1 s per image point, permitting an analysis made up of large numbers of points with high spatial resolution up to 850 dpi. The features of the software are demonstrated in this paper with samples of printed images, where visible images can be compared to those obtained by mass spectrometry. Quantitative aspects are introduced by analyzing a series of sample spots containing different amounts of several proteins. |
Mendeley readers
The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Belgium | 1 | 2% |
| Unknown | 55 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 16 | 28% |
| Student > Ph. D. Student | 13 | 23% |
| Student > Bachelor | 5 | 9% |
| Other | 5 | 9% |
| Professor | 4 | 7% |
| Other | 11 | 19% |
| Unknown | 3 | 5% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 20 | 35% |
| Agricultural and Biological Sciences | 15 | 26% |
| Biochemistry, Genetics and Molecular Biology | 9 | 16% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 5% |
| Mathematics | 1 | 2% |
| Other | 6 | 11% |
| Unknown | 3 | 5% |
Attention Score in Context
This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 September 2017.
All research outputs
#2,202,314
of 25,374,917 outputs
Outputs from Journal of the American Society for Mass Spectrometry
#80
of 3,835 outputs
Outputs of similar age
#2,607
of 109,593 outputs
Outputs of similar age from Journal of the American Society for Mass Spectrometry
#1
of 12 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,835 research outputs from this source. They receive a mean Attention Score of 3.8. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 109,593 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.