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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Polymorphisms in Plasmodium falciparum Chloroquine Resistance Transporter and Multidrug Resistance 1 Genes: Parasite Risk Factors That Affect Treatment Outcomes for P. falciparum Malaria After Artemether-Lumefantrine and Artesunate-Amodiaquine
|
|---|---|
| Published in |
The American Journal of Tropical Medicine and Hygiene, July 2014
|
| DOI | 10.4269/ajtmh.14-0031 |
| Pubmed ID | |
| Authors |
Meera Venkatesan, Nahla B Gadalla, Kasia Stepniewska, Prabin Dahal, Christian Nsanzabana, Clarissa Moriera, Ric N Price, Andreas Mårtensson, Philip J Rosenthal, Grant Dorsey, Colin J Sutherland, Philippe Guérin, Timothy M E Davis, Didier Ménard, Ishag Adam, George Ademowo, Cesar Arze, Frederick N Baliraine, Nicole Berens-Riha, Anders Björkman, Steffen Borrmann, Francesco Checchi, Meghna Desai, Mehul Dhorda, Abdoulaye A Djimdé, Badria B El-Sayed, Teferi Eshetu, Frederick Eyase, Catherine Falade, Jean-François Faucher, Gabrielle Fröberg, Anastasia Grivoyannis, Sally Hamour, Sandrine Houzé, Jacob Johnson, Erasmus Kamugisha, Simon Kariuki, Jean-René Kiechel, Fred Kironde, Poul-Erik Kofoed, Jacques LeBras, Maja Malmberg, Leah Mwai, Billy Ngasala, Francois Nosten, Samuel L Nsobya, Alexis Nzila, Mary Oguike, Sabina Dahlström Otienoburu, Bernhards Ogutu, Jean-Bosco Ouédraogo, Patrice Piola, Lars Rombo, Birgit Schramm, A Fabrice Somé, Julie Thwing, Johan Ursing, Rina P M Wong, Ahmed Zeynudin, Issaka Zongo, Christopher V Plowe, Carol Hopkins Sibley, Asaq Molecular Marker Study Group |
| Abstract |
Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the artemisinin component and the partner drug. Polymorphisms in the Plasmodium falciparum chloroquine resistance transporter (pfcrt) and P. falciparum multidrug resistance 1 (pfmdr1) genes are associated with decreased sensitivity to amodiaquine and lumefantrine, but effects of these polymorphisms on therapeutic responses to artesunate-amodiaquine (ASAQ) and artemether-lumefantrine (AL) have not been clearly defined. Individual patient data from 31 clinical trials were harmonized and pooled by using standardized methods from the WorldWide Antimalarial Resistance Network. Data for more than 7,000 patients were analyzed to assess relationships between parasite polymorphisms in pfcrt and pfmdr1 and clinically relevant outcomes after treatment with AL or ASAQ. Presence of the pfmdr1 gene N86 (adjusted hazards ratio = 4.74, 95% confidence interval = 2.29 - 9.78, P < 0.001) and increased pfmdr1 copy number (adjusted hazards ratio = 6.52, 95% confidence interval = 2.36-17.97, P < 0.001 : were significant independent risk factors for recrudescence in patients treated with AL. AL and ASAQ exerted opposing selective effects on single-nucleotide polymorphisms in pfcrt and pfmdr1. Monitoring selection and responding to emerging signs of drug resistance are critical tools for preserving efficacy of artemisinin combination therapies; determination of the prevalence of at least pfcrt K76T and pfmdr1 N86Y should now be routine. |
X Demographics
The data shown below were collected from the profiles of 18 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 33% |
| Côte d'Ivoire | 1 | 6% |
| Ecuador | 1 | 6% |
| United Kingdom | 1 | 6% |
| Argentina | 1 | 6% |
| South Africa | 1 | 6% |
| Unknown | 7 | 39% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 13 | 72% |
| Science communicators (journalists, bloggers, editors) | 2 | 11% |
| Practitioners (doctors, other healthcare professionals) | 2 | 11% |
| Scientists | 1 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 267 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | <1% |
| France | 1 | <1% |
| Burkina Faso | 1 | <1% |
| Sweden | 1 | <1% |
| Vietnam | 1 | <1% |
| Unknown | 261 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 48 | 18% |
| Student > Ph. D. Student | 45 | 17% |
| Student > Master | 43 | 16% |
| Student > Bachelor | 17 | 6% |
| Other | 15 | 6% |
| Other | 51 | 19% |
| Unknown | 48 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 55 | 21% |
| Agricultural and Biological Sciences | 50 | 19% |
| Medicine and Dentistry | 42 | 16% |
| Immunology and Microbiology | 12 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 3% |
| Other | 38 | 14% |
| Unknown | 61 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 20. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 November 2020.
All research outputs
#1,843,944
of 25,374,917 outputs
Outputs from The American Journal of Tropical Medicine and Hygiene
#465
of 9,523 outputs
Outputs of similar age
#18,089
of 239,679 outputs
Outputs of similar age from The American Journal of Tropical Medicine and Hygiene
#7
of 64 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,523 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.6. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 239,679 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 64 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.