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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Biological insights from 108 schizophrenia-associated genetic loci
|
|---|---|
| Published in |
Nature, July 2014
|
| DOI | 10.1038/nature13595 |
| Pubmed ID | |
| Abstract |
Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies. Here we report a multi-stage schizophrenia genome-wide association study of up to 36,989 cases and 113,075 controls. We identify 128 independent associations spanning 108 conservatively defined loci that meet genome-wide significance, 83 of which have not been previously reported. Associations were enriched among genes expressed in brain, providing biological plausibility for the findings. Many findings have the potential to provide entirely new insights into aetiology, but associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses. Independent of genes expressed in brain, associations were enriched among genes expressed in tissues that have important roles in immunity, providing support for the speculated link between the immune system and schizophrenia. |
X Demographics
The data shown below were collected from the profiles of 311 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 74 | 24% |
| United Kingdom | 46 | 15% |
| Sweden | 8 | 3% |
| Japan | 7 | 2% |
| Canada | 7 | 2% |
| Netherlands | 6 | 2% |
| Ireland | 6 | 2% |
| Spain | 6 | 2% |
| France | 5 | 2% |
| Other | 45 | 14% |
| Unknown | 101 | 32% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 206 | 66% |
| Scientists | 73 | 23% |
| Practitioners (doctors, other healthcare professionals) | 19 | 6% |
| Science communicators (journalists, bloggers, editors) | 13 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 5,584 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 56 | 1% |
| United Kingdom | 28 | <1% |
| Spain | 13 | <1% |
| Netherlands | 12 | <1% |
| Germany | 7 | <1% |
| France | 5 | <1% |
| Brazil | 5 | <1% |
| Switzerland | 5 | <1% |
| Italy | 4 | <1% |
| Other | 32 | <1% |
| Unknown | 5417 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 976 | 17% |
| Researcher | 855 | 15% |
| Student > Bachelor | 829 | 15% |
| Student > Master | 646 | 12% |
| Student > Doctoral Student | 289 | 5% |
| Other | 920 | 16% |
| Unknown | 1069 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 944 | 17% |
| Medicine and Dentistry | 828 | 15% |
| Neuroscience | 743 | 13% |
| Biochemistry, Genetics and Molecular Biology | 713 | 13% |
| Psychology | 496 | 9% |
| Other | 562 | 10% |
| Unknown | 1298 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1135. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 April 2024.
All research outputs
#13,296
of 25,734,859 outputs
Outputs from Nature
#1,340
of 98,631 outputs
Outputs of similar age
#66
of 240,094 outputs
Outputs of similar age from Nature
#8
of 964 outputs
Altmetric has tracked 25,734,859 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 98,631 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 102.7. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 240,094 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 964 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.