| Title |
The lncRNA PCAT29 Inhibits Oncogenic Phenotypes in Prostate Cancer
|
|---|---|
| Published in |
Molecular Cancer Research, August 2014
|
| DOI | 10.1158/1541-7786.mcr-14-0257 |
| Pubmed ID | |
| Authors |
Rohit Malik, Lalit Patel, John R Prensner, Yang Shi, Matthew K Iyer, Shruthi Subramaniyan, Alexander Carley, Yashar S Niknafs, Anirban Sahu, Sumin Han, Teng Ma, Meilan Liu, Irfan A Asangani, Xiaojun Jing, Xuhong Cao, Saravana M Dhanasekaran, Dan R Robinson, Felix Y Feng, Arul M Chinnaiyan |
| Abstract |
Long noncoding RNAs (lncRNAs) have recently been associated with the development and progression of a variety of human cancers. However, to date, the interplay between known oncogenic or tumor suppressive events and lncRNAs has not been well described. Here the novel lncRNA, Prostate Cancer-Associated Transcript 29 (PCAT29), is characterized along with its relationship to the androgen receptor (AR). PCAT29 is suppressed by dihydrotestosterone (DHT) and upregulated upon castration therapy in a prostate cancer xenograft model. PCAT29 knockdown significantly increased proliferation and migration of prostate cancer cells, while PCAT29 overexpression conferred the opposite effect and suppressed growth and metastases of prostate tumors in chick chorioallantoic membrane (CAM) assays. Finally, in prostate cancer patient specimens, low PCAT29 expression correlated with poor prognostic outcomes. Taken together, these data expose PCAT29 as an androgen-regulated tumor suppressor in prostate cancer. Implications: This study identifies PCAT29 as the first AR-repressed lncRNA that functions as a tumor suppressor and that its loss may identify a subset of patients at higher risk for disease recurrence. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Korea, Republic of | 1 | 2% |
| United Kingdom | 1 | 2% |
| Unknown | 61 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 15 | 24% |
| Student > Ph. D. Student | 13 | 21% |
| Student > Master | 9 | 14% |
| Student > Bachelor | 3 | 5% |
| Student > Postgraduate | 3 | 5% |
| Other | 8 | 13% |
| Unknown | 12 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 20 | 32% |
| Agricultural and Biological Sciences | 19 | 30% |
| Immunology and Microbiology | 2 | 3% |
| Engineering | 2 | 3% |
| Chemistry | 2 | 3% |
| Other | 5 | 8% |
| Unknown | 13 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 October 2023.
All research outputs
#6,941,088
of 22,758,963 outputs
Outputs from Molecular Cancer Research
#573
of 1,880 outputs
Outputs of similar age
#66,912
of 231,194 outputs
Outputs of similar age from Molecular Cancer Research
#8
of 24 outputs
Altmetric has tracked 22,758,963 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 1,880 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one has gotten more attention than average, scoring higher than 68% of its peers.
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We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.