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Exome sequencing reveals frequent inactivating mutations in ARID1A, ARID1B, ARID2 and ARID4A in microsatellite unstable colorectal cancer

Overview of attention for article published in International Journal of Cancer, January 2014
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  • Above-average Attention Score compared to outputs of the same age and source (57th percentile)

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3 X users
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1 patent

Citations

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110 Dimensions

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85 Mendeley
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1 CiteULike
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Title
Exome sequencing reveals frequent inactivating mutations in ARID1A, ARID1B, ARID2 and ARID4A in microsatellite unstable colorectal cancer
Published in
International Journal of Cancer, January 2014
DOI 10.1002/ijc.28705
Pubmed ID
Authors

Tatiana Cajuso, Ulrika A. Hänninen, Johanna Kondelin, Alexandra E. Gylfe, Tomas Tanskanen, Riku Katainen, Esa Pitkänen, Heikki Ristolainen, Eevi Kaasinen, Minna Taipale, Jussi Taipale, Jan Böhm, Laura Renkonen‐Sinisalo, Jukka‐Pekka Mecklin, Heikki Järvinen, Sari Tuupanen, Outi Kilpivaara, Pia Vahteristo

Abstract

ARID1A has been identified as a novel tumor suppressor gene in ovarian cancer and subsequently in various other tumor types. ARID1A belongs to the ARID domain containing gene family, which comprises of 15 genes involved, for example, in transcriptional regulation, proliferation and chromatin remodeling. In this study, we used exome sequencing data to analyze the mutation frequency of all the ARID domain containing genes in 25 microsatellite unstable (MSI) colorectal cancers (CRCs) as a first systematic effort to characterize the mutation pattern of the whole ARID gene family. Genes which fulfilled the selection criteria in this discovery set (mutations in at least 4/25 [16%] samples, including at least one nonsense or splice site mutation) were chosen for further analysis in an independent validation set of 21 MSI CRCs. We found that in addition to ARID1A, which was mutated in 39% of the tumors (18/46), also ARID1B (13%, 6/46), ARID2 (13%, 6/46) and ARID4A (20%, 9/46) were frequently mutated. In all these genes, the mutations were distributed along the entire length of the gene, thus distinguishing them from typical MSI target genes previously described. Our results indicate that in addition to ARID1A, other members of the ARID gene family may play a role in MSI CRC.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 85 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 5%
Japan 1 1%
Finland 1 1%
Unknown 79 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 23 27%
Researcher 11 13%
Student > Master 9 11%
Student > Bachelor 7 8%
Student > Doctoral Student 6 7%
Other 12 14%
Unknown 17 20%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 29 34%
Agricultural and Biological Sciences 19 22%
Medicine and Dentistry 16 19%
Computer Science 1 1%
Arts and Humanities 1 1%
Other 0 0%
Unknown 19 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 April 2017.
All research outputs
#7,047,954
of 25,374,917 outputs
Outputs from International Journal of Cancer
#4,367
of 12,204 outputs
Outputs of similar age
#76,674
of 320,221 outputs
Outputs of similar age from International Journal of Cancer
#44
of 105 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 12,204 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 320,221 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 105 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.