Title |
Synthesis of Silica Vesicles with Controlled Entrance Size for High Loading, Sustained Release, and Cellular Delivery of Therapeutical Proteins
|
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Published in |
Small, July 2014
|
DOI | 10.1002/smll.201401538 |
Pubmed ID | |
Authors |
Jun Zhang, Surajit Karmakar, Meihua Yu, Neena Mitter, Jin Zou, Chengzhong Yu |
Abstract |
A rationally designed two-step synthesis of silica vesicles is developed with the formation of vesicular structure in the first step and fine control over the entrance size by tuning the temperature in the second step. The silica vesicles have a uniform size of ≈50 nm with excellent cellular uptake performance. When the entrance size is equal to the wall thickness, silica vesicles after hydrophobic modification show the highest loading amount (563 mg/g) towards Ribonuclease A with a sustained release behavior. Consequently, the silica vesicles are excellent nano-carriers for cellular delivery applications of therapeutical biomolecules. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Spain | 1 | 4% |
Australia | 1 | 4% |
Unknown | 25 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 3 | 11% |
Other | 2 | 7% |
Student > Doctoral Student | 2 | 7% |
Student > Master | 2 | 7% |
Other | 5 | 19% |
Unknown | 4 | 15% |
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Immunology and Microbiology | 2 | 7% |
Materials Science | 2 | 7% |
Other | 6 | 22% |
Unknown | 6 | 22% |