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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Runx2 Is a Novel Regulator of Mammary Epithelial Cell Fate in Development and Breast Cancer
|
|---|---|
| Published in |
Cancer Research, September 2014
|
| DOI | 10.1158/0008-5472.can-14-0053 |
| Pubmed ID | |
| Authors |
Thomas W Owens, Renee L Rogers, Sarah Best, Anita Ledger, Anne-Marie Mooney, Alison Ferguson, Paul Shore, Alexander Swarbrick, Christopher J Ormandy, Peter T Simpson, Jason S Carroll, Jane Visvader, Matthew J Naylor |
| Abstract |
Regulators of differentiated cell fate can offer targets for managing cancer development and progression. Here we identify Runx2 as a new regulator of epithelial cell fate in mammary gland development and breast cancer. Runx2 is expressed in the epithelium of pregnant mice in a strict temporally and hormonally-regulated manner. During pregnancy, Runx2 genetic deletion impaired alveolar differentiation in a manner that disrupted alveolar progenitor cell populations. Conversely, exogenous transgenic expression of Runx2 in mammary epithelial cells blocked milk production, suggesting that the decrease in endogenous Runx2 observed late in pregnancy is necessary for full differentiation. In addition, overexpression of Runx2 drove EMT-like changes in normal mammary epithelial cells, while Runx2 deletion in basal breast cancer cells inhibited cellular phenotypes associated with tumorigenesis. Notably, loss of Runx2 expression increased tumor latency and enhanced overall survival in a mouse model of breast cancer, with Runx2-deficient tumors exhibiting reduced cell proliferation. Together, our results establish a novel function for Runx2 in breast cancer that may offer a novel generalized route for therapeutic interventions. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 50% |
| United States | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 123 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 2% |
| United States | 1 | <1% |
| France | 1 | <1% |
| Argentina | 1 | <1% |
| Unknown | 117 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 31 | 25% |
| Other | 26 | 21% |
| Student > Ph. D. Student | 16 | 13% |
| Student > Bachelor | 12 | 10% |
| Professor > Associate Professor | 6 | 5% |
| Other | 16 | 13% |
| Unknown | 16 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 58 | 47% |
| Biochemistry, Genetics and Molecular Biology | 23 | 19% |
| Medicine and Dentistry | 17 | 14% |
| Chemistry | 3 | 2% |
| Immunology and Microbiology | 1 | <1% |
| Other | 3 | 2% |
| Unknown | 18 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 September 2014.
All research outputs
#18,135,049
of 23,298,349 outputs
Outputs from Cancer Research
#15,633
of 18,072 outputs
Outputs of similar age
#167,280
of 247,260 outputs
Outputs of similar age from Cancer Research
#301
of 362 outputs
Altmetric has tracked 23,298,349 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 18,072 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one is in the 11th percentile – i.e., 11% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 247,260 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 362 others from the same source and published within six weeks on either side of this one. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.