| Title |
Focus on genetic and epigenetic events of colorectal cancer pathogenesis: implications for molecular diagnosis
|
|---|---|
| Published in |
Tumor Biology, March 2014
|
| DOI | 10.1007/s13277-014-1845-9 |
| Pubmed ID | |
| Authors |
Federica Zoratto, Luigi Rossi, Monica Verrico, Anselmo Papa, Enrico Basso, Angelo Zullo, Luigi Tomao, Adriana Romiti, Giuseppe Lo Russo, Silverio Tomao |
| Abstract |
Originally, colorectal cancer (CRC) tumorigenesis was understood as a multistep process that involved accumulation of tumor suppressor genes and oncogenes mutations, such as APC, TP53 and KRAS. However, this assumption proposed a relatively limited repertoire of genetic alterations. In the last decade, there have been major advances in knowledge of multiple molecular pathways involved in CRC pathogenesis, particularly regarding cytogenetic and epigenetic events. Microsatellite instability, chromosomal instability and CpG island methylator phenotype are the most analyzed cytogenetic changes, while DNA methylation, modifications in histone proteins and microRNAs (miRNAs) were analyzed in the field of epigenetic alterations. Therefore, CRC development results from interactions at many levels between genetic and epigenetic amendments. Furthermore, hereditary cancer syndrome and individual or environmental risk factors should not be ignored. The difficulties in this setting are addressed to understand the molecular basis of individual susceptibility to CRC and to determine the roles of genetic and epigenetic alterations, in order to yield more effective prevention strategies in CRC patients and directing their treatment. This review summarizes the most investigated biomolecular pathways involved in CRC pathogenesis, their role as biomarkers for early CRC diagnosis and their possible use to stratify susceptible patients into appropriate screening or surveillance programs. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 113 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 2 | 2% |
| Unknown | 111 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 21 | 19% |
| Researcher | 18 | 16% |
| Student > Master | 17 | 15% |
| Student > Bachelor | 15 | 13% |
| Student > Doctoral Student | 9 | 8% |
| Other | 12 | 11% |
| Unknown | 21 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 35 | 31% |
| Biochemistry, Genetics and Molecular Biology | 22 | 19% |
| Agricultural and Biological Sciences | 22 | 19% |
| Nursing and Health Professions | 4 | 4% |
| Chemistry | 2 | 2% |
| Other | 5 | 4% |
| Unknown | 23 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 July 2014.
All research outputs
#20,233,066
of 22,758,963 outputs
Outputs from Tumor Biology
#1,834
of 2,622 outputs
Outputs of similar age
#192,321
of 224,814 outputs
Outputs of similar age from Tumor Biology
#47
of 73 outputs
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