Title |
Rationale and design of the SOluble guanylate Cyclase stimulatoR in heArT failurE Studies (SOCRATES)
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Published in |
European Journal of Heart Failure, July 2014
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DOI | 10.1002/ejhf.135 |
Pubmed ID | |
Authors |
Burkert Pieske, Javed Butler, Gerasimos Filippatos, Carolyn Lam, Aldo Pietro Maggioni, Piotr Ponikowski, Sanjiv Shah, Scott Solomon, Elisabeth Kraigher‐Krainer, Eliana Tibana Samano, Andrea Viviana Scalise, Katharina Müller, Lothar Roessig, Mihai Gheorghiade, on behalf of the SOCRATES Investigators and Coordinators |
Abstract |
The clinical outcomes for patients with worsening chronic heart failure (WCHF) remain exceedingly poor despite contemporary evidence-based therapies, and effective therapies are urgently needed. Accumulating evidence supports augmentation of cyclic guanosine monophosphate (cGMP) signalling as a potential therapeutic strategy for HF with reduced or preserved ejection fraction (HFrEF and HFpEF, respectively). Direct soluble guanylate cyclase (sGC) stimulators target reduced cGMP generation due to insufficient sGC stimulation and represent a promising method for cGMP enhancement. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Ukraine | 1 | <1% |
Germany | 1 | <1% |
Unknown | 114 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 15 | 13% |
Student > Ph. D. Student | 13 | 11% |
Other | 12 | 10% |
Professor | 9 | 8% |
Student > Doctoral Student | 9 | 8% |
Other | 20 | 17% |
Unknown | 38 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 56 | 48% |
Biochemistry, Genetics and Molecular Biology | 4 | 3% |
Nursing and Health Professions | 4 | 3% |
Agricultural and Biological Sciences | 2 | 2% |
Chemistry | 2 | 2% |
Other | 6 | 5% |
Unknown | 42 | 36% |