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Sequence, Structural and Expression Divergence of Duplicate Genes in the Bovine Genome

Overview of attention for article published in PLOS ONE, July 2014
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  • Good Attention Score compared to outputs of the same age (72nd percentile)
  • Good Attention Score compared to outputs of the same age and source (67th percentile)

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Title
Sequence, Structural and Expression Divergence of Duplicate Genes in the Bovine Genome
Published in
PLOS ONE, July 2014
DOI 10.1371/journal.pone.0102868
Pubmed ID
Authors

Xiaoping Liao, Hua Bao, Yan Meng, Graham Plastow, Stephen Moore, Paul Stothard

Abstract

Gene duplication is a widespread phenomenon in genome evolution, and it has been proposed to serve as an engine of evolutionary innovation. In the present study, we performed the first comprehensive analysis of duplicate genes in the bovine genome. A total of 3131 putative duplicated gene pairs were identified, including 712 cattle-specific duplicate gene pairs unevenly distributed across the genome, which are significantly enriched for specific biological functions including immunity, growth, digestion, reproduction, embryonic development, inflammatory response, and defense response to bacterium. Around 97.1% (87.8%) of (cattle-specific) duplicate gene pairs were found to have distinct exon-intron structures. Analysis of gene expression by RNA-Seq and sequence divergence (synonymous or non-synonymous) revealed that expression divergence is correlated with sequence divergence, as has been previously observed in other species. This analysis also led to the identification of a subset of cattle-specific duplicate gene pairs exhibiting very high expression divergence. Interestingly, further investigation revealed a significant relationship between structural and expression divergence while controlling for the effect of synonymous sequence divergence. Together these results provide further insight into duplicate gene sequence and expression divergence in cattle, and their potential contributions to phenotypic divergence.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 3%
Brazil 1 3%
Unknown 33 94%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 17%
Researcher 6 17%
Professor 3 9%
Student > Ph. D. Student 3 9%
Student > Doctoral Student 1 3%
Other 5 14%
Unknown 11 31%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 40%
Biochemistry, Genetics and Molecular Biology 6 17%
Medicine and Dentistry 2 6%
Unspecified 1 3%
Unknown 12 34%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 April 2015.
All research outputs
#6,697,056
of 22,758,963 outputs
Outputs from PLOS ONE
#79,068
of 194,194 outputs
Outputs of similar age
#63,612
of 228,654 outputs
Outputs of similar age from PLOS ONE
#1,565
of 4,794 outputs
Altmetric has tracked 22,758,963 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 194,194 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.1. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 228,654 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 4,794 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.