Title |
Influenza vaccine as prevention for cardiovascular diseases: Possible molecular mechanism
|
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Published in |
Vaccine, July 2014
|
DOI | 10.1016/j.vaccine.2014.07.007 |
Pubmed ID | |
Authors |
Veljko Veljkovic, Sanja Glisic, Nevena Veljkovic, Tijana Bojic, Ursula Dietrich, Vladimir R. Perovic, Alfonso Colombatti |
Abstract |
Despite plausible evidence for beneficial effects of the vaccination against influenza in cardiovascular diseases (CVD) very limited studies have been carried out to explain the molecular mechanism of this phenomenon. Using the informational spectrum method (ISM), a virtual spectroscopy method for analysis of protein-protein interactions, the bradykinin 2 receptor (BKB2R) was identified as a principal host protein which could mediate molecular processes underlying the cardioprotective effect of influenza vaccines. Based on this finding we suggest that some antibodies elicited by influenza vaccines act as agonists, which activate a BKB2R-associated signaling pathway contributing to the protection against CVD. The ISM analysis of 14 influenza viruses, which were used as components of seasonal vaccines, revealed four vaccine viruses A/Beijing/262/95(H1N1), A/NewCaledonia/20/1999(H1N1), A/Christchurch/28/2003(H3N2) and A/Perth/16/2009(H3N2), which could be suited best for further studies on the cardioprotective effect of influenza vaccines. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 33% |
Spain | 1 | 17% |
United Kingdom | 1 | 17% |
Germany | 1 | 17% |
Unknown | 1 | 17% |
Demographic breakdown
Type | Count | As % |
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Scientists | 3 | 50% |
Members of the public | 3 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 2% |
Unknown | 50 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 9 | 18% |
Researcher | 9 | 18% |
Student > Ph. D. Student | 7 | 14% |
Student > Bachelor | 5 | 10% |
Other | 4 | 8% |
Other | 11 | 22% |
Unknown | 6 | 12% |
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Medicine and Dentistry | 17 | 33% |
Agricultural and Biological Sciences | 8 | 16% |
Biochemistry, Genetics and Molecular Biology | 4 | 8% |
Immunology and Microbiology | 4 | 8% |
Nursing and Health Professions | 3 | 6% |
Other | 6 | 12% |
Unknown | 9 | 18% |