| Title |
Outcome of extremely low birth weight survivors at school age: the influence of perinatal parameters on neurodevelopment
|
|---|---|
| Published in |
European Journal of Pediatrics, February 2007
|
| DOI | 10.1007/s00431-007-0435-x |
| Pubmed ID | |
| Authors |
Achim-Peter Neubauer, Wolfgang Voss, Evelyn Kattner |
| Abstract |
Extremely low birth weight (ELBW) is associated with impaired neurodevelopmental outcome in infancy. Information on the long-term cognitive and neurological consequences of ELBW is scarce. We aimed to identify the perinatal and neonatal factors of ELBW infants associated with adverse cognitive and neurological outcome at school age. A regional cohort of 135 ELBW infants born between 1993 and 1998 was prospectively evaluated at 3, 6, 12, and 18 months postmenstrual age and at yearly intervals up to age 10 years. The comprehensive follow-up programme for high-risk infants included neurological examinations and psychometric evaluations. According to the overall results of these tests, children were classified as either being normal or having minor or major impairment. At a mean age of 8.4 (SD: 1.6) years, 43% of children had survived without any impairment. Minor impairment was diagnosed in 39% and major impairment in 18% of assessed children. The proportion of disabled school children rose with decreasing gestational age. The following neonatal complications were significant risk factors for developing major or minor impairment at school age: an increase in head circumference < 6 mm per week (OR 4.0, 95% CI: 1.1-14.8), parenteral nutrition > or = 6 weeks (OR 2.5, 95% CI: 1.1-6.0), and mechanical ventilation > 14 days (OR 2.3, 95% CI: 1.0-5.1). High-grade intraventricular haemorrhage (IVH) and/or PVL (OR 13.3, 95% CI: 4.0-44.9), neonatal seizures (OR 5.2, 95% CI: 1.2-22.4) and bowel perforation, and/or necrotizing enterocolitis (OR 4.4, 95% CI: 1.1-17.0) were significant risk factors for developing major impairment. In spite of the relatively large proportion of normal children, ELBW remains an important risk factor for neurodevelopmental impairment at school age. Thus, measures to prevent complications such as necrotizing enterocolitis, cerebral haemorrhage, and undernutrition remain important goals for neonatal intensive care. |
Mendeley readers
The data shown below were compiled from readership statistics for 133 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| Spain | 2 | 2% |
| Colombia | 1 | <1% |
| Brazil | 1 | <1% |
| Germany | 1 | <1% |
| Switzerland | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 124 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 20 | 15% |
| Student > Master | 19 | 14% |
| Student > Ph. D. Student | 16 | 12% |
| Student > Doctoral Student | 12 | 9% |
| Student > Bachelor | 9 | 7% |
| Other | 32 | 24% |
| Unknown | 25 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 59 | 44% |
| Psychology | 13 | 10% |
| Social Sciences | 6 | 5% |
| Nursing and Health Professions | 6 | 5% |
| Neuroscience | 5 | 4% |
| Other | 13 | 10% |
| Unknown | 31 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 July 2017.
All research outputs
#7,444,997
of 22,758,963 outputs
Outputs from European Journal of Pediatrics
#1,457
of 3,686 outputs
Outputs of similar age
#27,081
of 75,916 outputs
Outputs of similar age from European Journal of Pediatrics
#11
of 24 outputs
Altmetric has tracked 22,758,963 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,686 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 41st percentile – i.e., 41% of its peers scored the same or lower than it.
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We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.