| Title |
Chemotherapy of MMR-deficient colorectal cancer
|
|---|---|
| Published in |
Familial Cancer, March 2013
|
| DOI | 10.1007/s10689-013-9633-z |
| Pubmed ID | |
| Authors |
N. Devaud, S. Gallinger |
| Abstract |
Colorectal cancer (CRC) continues to rank as the third most common cancer in Western society and the second leading cause of cancer death in North America. There are at least three distinct, and relatively discreet, molecular pathways associated with this disease: chromosomal instability (CIN), microsatellite instability (MSI) and the cytosine polyguanine island methylator phenotype. Defects in the DNA mismatch repair system (MMR) account for the MSI phenotype and genotype of about 15 % of CRC. Although high frequency MSI tumors have better stage independent prognosis compared to those with CIN, MMR deficient CRC appears to be resistant to fluorouracil based treatment, but sensitive to other therapeutic regimens. This review summarises current literature on differential chemosensitivity of MMR-deficient CRC. |
Mendeley readers
The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 2% |
| Unknown | 46 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 9 | 19% |
| Student > Master | 9 | 19% |
| Student > Ph. D. Student | 7 | 15% |
| Researcher | 5 | 11% |
| Student > Doctoral Student | 4 | 9% |
| Other | 4 | 9% |
| Unknown | 9 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 12 | 26% |
| Agricultural and Biological Sciences | 12 | 26% |
| Medicine and Dentistry | 11 | 23% |
| Immunology and Microbiology | 3 | 6% |
| Neuroscience | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 7 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 September 2022.
All research outputs
#7,702,488
of 23,426,104 outputs
Outputs from Familial Cancer
#168
of 571 outputs
Outputs of similar age
#66,811
of 200,402 outputs
Outputs of similar age from Familial Cancer
#11
of 24 outputs
Altmetric has tracked 23,426,104 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 571 research outputs from this source. They receive a mean Attention Score of 4.2. This one has gotten more attention than average, scoring higher than 59% of its peers.
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We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.