| Title |
Physiological and pathological consequences of cellular senescence
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, July 2014
|
| DOI | 10.1007/s00018-014-1691-3 |
| Pubmed ID | |
| Authors |
Dominick G. A. Burton, Valery Krizhanovsky |
| Abstract |
Cellular senescence, a permanent state of cell cycle arrest accompanied by a complex phenotype, is an essential mechanism that limits tumorigenesis and tissue damage. In physiological conditions, senescent cells can be removed by the immune system, facilitating tumor suppression and wound healing. However, as we age, senescent cells accumulate in tissues, either because an aging immune system fails to remove them, the rate of senescent cell formation is elevated, or both. If senescent cells persist in tissues, they have the potential to paradoxically promote pathological conditions. Cellular senescence is associated with an enhanced pro-survival phenotype, which most likely promotes persistence of senescent cells in vivo. This phenotype may have evolved to favor facilitation of a short-term wound healing, followed by the elimination of senescent cells by the immune system. In this review, we provide a perspective on the triggers, mechanisms and physiological as well as pathological consequences of senescent cells. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 40% |
| United Kingdom | 1 | 20% |
| Unknown | 2 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 373 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | <1% |
| France | 1 | <1% |
| Austria | 1 | <1% |
| United Kingdom | 1 | <1% |
| China | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 367 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 69 | 18% |
| Student > Master | 65 | 17% |
| Student > Bachelor | 60 | 16% |
| Researcher | 51 | 14% |
| Student > Doctoral Student | 16 | 4% |
| Other | 33 | 9% |
| Unknown | 79 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 106 | 28% |
| Agricultural and Biological Sciences | 78 | 21% |
| Medicine and Dentistry | 45 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 14 | 4% |
| Immunology and Microbiology | 8 | 2% |
| Other | 35 | 9% |
| Unknown | 87 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 22. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 April 2023.
All research outputs
#1,537,515
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#152
of 4,151 outputs
Outputs of similar age
#15,986
of 229,907 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#4
of 40 outputs
Altmetric has tracked 23,794,258 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,151 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 229,907 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 40 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.