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Multi-responsive hydrogels derived from the self-assembly of tethered allyl-functionalized racemic oligopeptides

Overview of attention for article published in Journal of Materials Chemistry B: Materials for biology and medicine, January 2014
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Title
Multi-responsive hydrogels derived from the self-assembly of tethered allyl-functionalized racemic oligopeptides
Published in
Journal of Materials Chemistry B: Materials for biology and medicine, January 2014
DOI 10.1039/c4tb00909f
Pubmed ID
Authors

Xun He, Jingwei Fan, Fuwu Zhang, Richen Li, Kevin A Pollack, Jeffery E Raymond, Jiong Zou, Karen L Wooley

Abstract

A multi-responsive triblock hydrogelator oligo(dl-allylglycine)-block-poly(ethylene glycol)-block-oligo(dl-allylglycine) (ODLAG-b-PEG-b-ODLAG) was synthesized facilely by ring-opening polymerization (ROP) of DLAG N-carboxyanhydride (NCA) with a diamino-terminated PEG as the macroinitiator. This system exhibited heat-induced sol-to-gel transitions and either sonication- or enzyme-induced gel-to-sol transitions. The β-sheeting of the oligopeptide segments was confirmed by attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) and wide-angle X-ray scattering (WAXS). The β-sheets further displayed tertiary ordering into fibrillar structures that, in turn generated a porous and interconnected hydrogel matrix, as observed via transmission electron microscopy (TEM) and scanning electron microscopy (SEM). The reversible macroscopic sol-to-gel transitions triggered by heat and gel-to-sol transitions triggered by sonication were correlated with the transformation of nanostructural morphologies, with fibrillar structures observed in gel and spherical aggregates in sol, respectively. The enzymatic breakdown of the hydrogels was also investigated. This allyl-functionalized hydrogelator can serve as a platform for the design of smart hydrogels, appropriate for expansion into biological systems as bio-functional and bio-responsive materials.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 4%
Germany 1 4%
Unknown 25 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 37%
Researcher 6 22%
Student > Bachelor 3 11%
Student > Master 2 7%
Student > Doctoral Student 1 4%
Other 0 0%
Unknown 5 19%
Readers by discipline Count As %
Chemistry 10 37%
Materials Science 7 26%
Physics and Astronomy 1 4%
Agricultural and Biological Sciences 1 4%
Engineering 1 4%
Other 0 0%
Unknown 7 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 July 2014.
All research outputs
#20,970,494
of 25,756,911 outputs
Outputs from Journal of Materials Chemistry B: Materials for biology and medicine
#2,521
of 5,583 outputs
Outputs of similar age
#245,443
of 321,307 outputs
Outputs of similar age from Journal of Materials Chemistry B: Materials for biology and medicine
#154
of 182 outputs
Altmetric has tracked 25,756,911 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,583 research outputs from this source. They receive a mean Attention Score of 2.0. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
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We're also able to compare this research output to 182 others from the same source and published within six weeks on either side of this one. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.