Title |
MicroRNA-18a inhibits hypoxia-inducible factor 1α activity and lung metastasis in basal breast cancers
|
---|---|
Published in |
Breast Cancer Research, July 2014
|
DOI | 10.1186/bcr3693 |
Pubmed ID | |
Authors |
Raisa Krutilina, Wenlin Sun, Aarti Sethuraman, Martin Brown, Tiffany N Seagroves, Lawrence M Pfeffer, Tatyana Ignatova, Meiyun Fan |
Abstract |
In breast cancer, distinct expression profiles of miRNAs (microRNAs) have been associated with molecular subgroups and clinicopathological characteristics, implicating a diagnostic and prognostic role of miRNAs. However, the biological functions of deregulated miRNAs in tumor progression are not completely defined. In this study, we investigated the function of miR-18a (microRNA-18a) in regulating breast cancer metastasis through the HIF1A (hypoxia-inducible factor 1alpha) -dependent hypoxic response. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 67% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 76 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 19 | 25% |
Student > Master | 12 | 16% |
Researcher | 11 | 14% |
Student > Bachelor | 6 | 8% |
Professor > Associate Professor | 4 | 5% |
Other | 11 | 14% |
Unknown | 13 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 18 | 24% |
Biochemistry, Genetics and Molecular Biology | 18 | 24% |
Agricultural and Biological Sciences | 14 | 18% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 4% |
Immunology and Microbiology | 2 | 3% |
Other | 4 | 5% |
Unknown | 17 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 October 2014.
All research outputs
#17,285,036
of 25,373,627 outputs
Outputs from Breast Cancer Research
#1,534
of 2,052 outputs
Outputs of similar age
#142,979
of 239,924 outputs
Outputs of similar age from Breast Cancer Research
#25
of 36 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,052 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.2. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
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We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.