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Mendeley readers
Attention Score in Context
| Title |
Synthesis, DNA-binding abilities and anticancer activities of triazole-pyrrolo[2,1-c][1,4]benzodiazepines hybrid scaffolds
|
|---|---|
| Published in |
Bioorganic & Medicinal Chemistry Letters, October 2013
|
| DOI | 10.1016/j.bmcl.2013.10.004 |
| Pubmed ID | |
| Authors |
Chung-Yu Chen, Pei-Hua Lee, Yong-Yong Lin, Wen-Ting Yu, Wan-Ping Hu, Chia-Chen Hsu, Ying-Ting Lin, Long-Sen Chang, Cheng-Tien Hsiao, Jeh-Jeng Wang, Mei-Ing Chung |
| Abstract |
We synthesized a new series of PBD-hybrid derivatives having tethered triazoles and investigated for their cytotoxicity. The studies indicated that cis-olefin compounds induce higher cytotoxicity with increase in the G1 cell cycle phase compared with the trans-compounds. Quantitative RT-PCR assay indicated that compounds (16a-d) induced G1 phase arrest through down-regulation of cyclin D1 and up-regulation of p21, p27, and p53 mRNA expressions. Compounds 16a-d induced A375 early apoptosis as detected by flow cytometry after double-staining with annexin V and propidium iodide. Moreover, the Western blot analysis showed that A375 treated by compounds (16a-d) resulted in decreased levels of Bcl-2 and Bcl-xL, increased levels of Bax and Bad, and caspase/PARP degradation to identify apoptotic cells. |
Mendeley readers
The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Ireland | 1 | 6% |
| Unknown | 16 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 3 | 18% |
| Researcher | 3 | 18% |
| Student > Bachelor | 2 | 12% |
| Professor > Associate Professor | 2 | 12% |
| Student > Master | 1 | 6% |
| Other | 3 | 18% |
| Unknown | 3 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 6 | 35% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 18% |
| Chemistry | 3 | 18% |
| Medicine and Dentistry | 1 | 6% |
| Biochemistry, Genetics and Molecular Biology | 1 | 6% |
| Other | 0 | 0% |
| Unknown | 3 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 October 2014.
All research outputs
#2,485,702
of 25,374,917 outputs
Outputs from Bioorganic & Medicinal Chemistry Letters
#302
of 13,778 outputs
Outputs of similar age
#22,303
of 222,787 outputs
Outputs of similar age from Bioorganic & Medicinal Chemistry Letters
#5
of 95 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 13,778 research outputs from this source. They receive a mean Attention Score of 4.9. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 222,787 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 95 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.