| Title |
The regenerative effect of platelet-rich plasma on healing in large osteochondral defects
|
|---|---|
| Published in |
International Orthopaedics, May 2009
|
| DOI | 10.1007/s00264-009-0793-2 |
| Pubmed ID | |
| Authors |
Y. Sun, Y. Feng, C. Q. Zhang, S. B. Chen, X. G. Cheng |
| Abstract |
Platelet-rich plasma (PRP), a platelet concentrate made of autogenous blood, has been used to improve bone and soft tissue defect healing in recent years. The aim of this study was to assess the effect of PRP on articular cartilage defects in a rabbit model. Forty-eight osteochondral defects created in the femoropatellar groove were (a) left untreated, (b) treated with autogenous PRP in a poly-lactic-glycolic acid (PLGA), or (c) with PLGA alone. Platelets were enriched 5.12-fold compared to normal blood in the PRP. After four and 12 weeks, the explanted tissue specimens were assessed by macroscopic examination, micro-computed tomography, and histological evaluation. Macroscopic examination, micro-computed tomography and histology of the newly formed cartilage and bone in the defect differ significantly between the PRP-treated and the untreated groups, and stimulatory effect of PRP on osteochondral formation was observed. In conclusion, PRP in PLGA improves osteochondral healing in a rabbit model. |
Mendeley readers
The data shown below were compiled from readership statistics for 133 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| Korea, Republic of | 1 | <1% |
| Italy | 1 | <1% |
| Norway | 1 | <1% |
| Singapore | 1 | <1% |
| Austria | 1 | <1% |
| Japan | 1 | <1% |
| Mexico | 1 | <1% |
| Unknown | 124 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 20 | 15% |
| Student > Postgraduate | 18 | 14% |
| Student > Ph. D. Student | 16 | 12% |
| Student > Master | 16 | 12% |
| Student > Bachelor | 12 | 9% |
| Other | 34 | 26% |
| Unknown | 17 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 65 | 49% |
| Agricultural and Biological Sciences | 14 | 11% |
| Veterinary Science and Veterinary Medicine | 9 | 7% |
| Biochemistry, Genetics and Molecular Biology | 7 | 5% |
| Nursing and Health Professions | 4 | 3% |
| Other | 8 | 6% |
| Unknown | 26 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 August 2015.
All research outputs
#7,200,861
of 22,759,618 outputs
Outputs from International Orthopaedics
#400
of 1,425 outputs
Outputs of similar age
#31,922
of 92,342 outputs
Outputs of similar age from International Orthopaedics
#10
of 18 outputs
Altmetric has tracked 22,759,618 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 1,425 research outputs from this source. They receive a mean Attention Score of 4.2. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 92,342 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.