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Impulsivity-related cognition in alcohol dependence: Is it moderated by DRD2/ANKK1 gene status and executive dysfunction?

Overview of attention for article published in Addictive Behaviors, February 2014
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Title
Impulsivity-related cognition in alcohol dependence: Is it moderated by DRD2/ANKK1 gene status and executive dysfunction?
Published in
Addictive Behaviors, February 2014
DOI 10.1016/j.addbeh.2014.02.004
Pubmed ID
Authors

Matthew J. Gullo, Nathan St. John, Ross McD. Young, John B. Saunders, Ernest P. Noble, Jason P. Connor

Abstract

Perceived impaired control over alcohol use is a key cognitive construct in alcohol dependence that has been related prospectively to treatment outcome and may mediate the risk for problem drinking conveyed by impulsivity in non-dependent drinkers. The aim of the current study was to investigate whether perceived impaired control may mediate the association between impulsivity-related measures (derived from the Short-form Eysenck Personality Questionnaire-Revised) and alcohol-dependence severity in alcohol-dependent drinkers. Furthermore, the extent to which this hypothesized relationship was moderated by genetic risk (Taq1A polymorphism in the DRD2/ANKK1 gene cluster) and verbal fluency as an indicator of executive cognitive ability (Controlled Oral Word Association Test) was also examined. A sample of 143 alcohol-dependent inpatients provided an extensive clinical history of their alcohol use, gave 10ml of blood for DNA analysis, and completed self-report measures relating to impulsivity, impaired control and severity of dependence. As hypothesized, perceived impaired control (partially) mediated the association between impulsivity-related measures and alcohol-dependence severity. This relationship was not moderated by the DRD2/ANKK1 polymorphism or verbal fluency. These results suggest that, in alcohol dependence, perceived impaired control is a cognitive mediator of impulsivity-related constructs that may be unaffected by DRD2/ANKK1 and neurocognitive processes underlying the retrieval of verbal information.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 83 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
Spain 1 1%
Australia 1 1%
Unknown 80 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 14 17%
Researcher 13 16%
Student > Bachelor 12 14%
Student > Doctoral Student 9 11%
Student > Master 8 10%
Other 13 16%
Unknown 14 17%
Readers by discipline Count As %
Psychology 34 41%
Medicine and Dentistry 9 11%
Agricultural and Biological Sciences 5 6%
Social Sciences 4 5%
Biochemistry, Genetics and Molecular Biology 2 2%
Other 10 12%
Unknown 19 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 July 2014.
All research outputs
#22,756,649
of 25,371,288 outputs
Outputs from Addictive Behaviors
#3,928
of 4,433 outputs
Outputs of similar age
#302,289
of 345,120 outputs
Outputs of similar age from Addictive Behaviors
#49
of 50 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,433 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.5. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 50 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.