Title |
Impulsivity-related cognition in alcohol dependence: Is it moderated by DRD2/ANKK1 gene status and executive dysfunction?
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Published in |
Addictive Behaviors, February 2014
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DOI | 10.1016/j.addbeh.2014.02.004 |
Pubmed ID | |
Authors |
Matthew J. Gullo, Nathan St. John, Ross McD. Young, John B. Saunders, Ernest P. Noble, Jason P. Connor |
Abstract |
Perceived impaired control over alcohol use is a key cognitive construct in alcohol dependence that has been related prospectively to treatment outcome and may mediate the risk for problem drinking conveyed by impulsivity in non-dependent drinkers. The aim of the current study was to investigate whether perceived impaired control may mediate the association between impulsivity-related measures (derived from the Short-form Eysenck Personality Questionnaire-Revised) and alcohol-dependence severity in alcohol-dependent drinkers. Furthermore, the extent to which this hypothesized relationship was moderated by genetic risk (Taq1A polymorphism in the DRD2/ANKK1 gene cluster) and verbal fluency as an indicator of executive cognitive ability (Controlled Oral Word Association Test) was also examined. A sample of 143 alcohol-dependent inpatients provided an extensive clinical history of their alcohol use, gave 10ml of blood for DNA analysis, and completed self-report measures relating to impulsivity, impaired control and severity of dependence. As hypothesized, perceived impaired control (partially) mediated the association between impulsivity-related measures and alcohol-dependence severity. This relationship was not moderated by the DRD2/ANKK1 polymorphism or verbal fluency. These results suggest that, in alcohol dependence, perceived impaired control is a cognitive mediator of impulsivity-related constructs that may be unaffected by DRD2/ANKK1 and neurocognitive processes underlying the retrieval of verbal information. |
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Australia | 1 | 1% |
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Demographic breakdown
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Researcher | 13 | 16% |
Student > Bachelor | 12 | 14% |
Student > Doctoral Student | 9 | 11% |
Student > Master | 8 | 10% |
Other | 13 | 16% |
Unknown | 14 | 17% |
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Social Sciences | 4 | 5% |
Biochemistry, Genetics and Molecular Biology | 2 | 2% |
Other | 10 | 12% |
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