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A phase 2, randomized, double-blind safety and pharmacokinetic assessment of respiratory syncytial virus (RSV) prophylaxis with motavizumab and palivizumab administered in the same season

Overview of attention for article published in BMC Pediatrics, June 2010
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Title
A phase 2, randomized, double-blind safety and pharmacokinetic assessment of respiratory syncytial virus (RSV) prophylaxis with motavizumab and palivizumab administered in the same season
Published in
BMC Pediatrics, June 2010
DOI 10.1186/1471-2431-10-38
Pubmed ID
Authors

Pilar Fernández, Adrian Trenholme, Katia Abarca, M Pamela Griffin, Micki Hultquist, Brian Harris, Genevieve A Losonsky, the Motavizumab Study Group

Abstract

Respiratory syncytial virus (RSV) is an important pathogen causing annual epidemics of bronchiolitis and pneumonia among infants worldwide. High-risk infants currently receive RSV prophylaxis with palivizumab, a humanized RSV monoclonal antibody (MAb). In preclinical in vitro and in vivo (cotton-rat model) studies, motavizumab, a new RSV MAb, was shown to have greater anti-RSV activity than palivizumab. Motavizumab is currently under review for licensing approval. Since both MAbs may be available concurrently, this study evaluated their safety and tolerability when administered sequentially during the same RSV season.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Belgium 1 2%
Unknown 63 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 16%
Researcher 10 16%
Student > Bachelor 9 14%
Student > Master 9 14%
Other 4 6%
Other 5 8%
Unknown 17 27%
Readers by discipline Count As %
Medicine and Dentistry 25 39%
Agricultural and Biological Sciences 8 13%
Pharmacology, Toxicology and Pharmaceutical Science 3 5%
Biochemistry, Genetics and Molecular Biology 3 5%
Nursing and Health Professions 2 3%
Other 5 8%
Unknown 18 28%