Title |
Transmembrane Protein 55B Is a Novel Regulator of Cellular Cholesterol Metabolism
|
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Published in |
Arteriosclerosis, Thrombosis, and Vascular Biology (Highwire), July 2014
|
DOI | 10.1161/atvbaha.113.302806 |
Pubmed ID | |
Authors |
Marisa W Medina, Frederick Bauzon, Devesh Naidoo, Elizabeth Theusch, Kristen Stevens, Jessica Schilde, Christian Schubert, Lara M Mangravite, Lawrence L Rudel, Ryan E Temel, Heiko Runz, Ronald M Krauss |
Abstract |
Interindividual variation in pathways affecting cellular cholesterol metabolism can influence levels of plasma cholesterol, a well-established risk factor for cardiovascular disease. Inherent variation among immortalized lymphoblastoid cell lines from different donors can be leveraged to discover novel genes that modulate cellular cholesterol metabolism. The objective of this study was to identify novel genes that regulate cholesterol metabolism by testing for evidence of correlated gene expression with cellular levels of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) mRNA, a marker for cellular cholesterol homeostasis, in a large panel of lymphoblastoid cell lines. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 25% |
Canada | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 75% |
Scientists | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 32 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 7 | 22% |
Researcher | 6 | 19% |
Student > Bachelor | 5 | 16% |
Other | 3 | 9% |
Lecturer | 2 | 6% |
Other | 4 | 13% |
Unknown | 5 | 16% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 10 | 31% |
Agricultural and Biological Sciences | 7 | 22% |
Medicine and Dentistry | 6 | 19% |
Psychology | 1 | 3% |
Sports and Recreations | 1 | 3% |
Other | 1 | 3% |
Unknown | 6 | 19% |