Title |
Screening and identification of neuroprotective compounds relevant to Alzheimer׳s disease from medicinal plants of S. Tomé e Príncipe
|
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Published in |
Journal of Ethnopharmacology, June 2014
|
DOI | 10.1016/j.jep.2014.06.046 |
Pubmed ID | |
Authors |
Antonio Currais, Chandramouli Chiruta, Marie Goujon-Svrzic, Gustavo Costa, Tânia Santos, Maria Teresa Batista, Jorge Paiva, Maria do Céu Madureira, Pamela Maher |
Abstract |
Alzheimer׳s disease (AD) neuropathology is strongly associated with the activation of inflammatory pathways, and long-term use of anti-inflammatory drugs reduces the risk of developing the disease. In S. Tomé e Príncipe (STP), several medicinal plants are used both for their positive effects in the nervous system (treatment of mental disorders, analgesics) and their anti-inflammatory properties. The goal of this study was to determine whether a phenotypic, cell-based screening approach can be applied to selected plants from STP (Voacanga africana, Tarenna nitiduloides, Sacosperma paniculatum, Psychotria principensis, Psychotria subobliqua) in order to identify natural compounds with multiple biological activities of interest for AD therapeutics. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Portugal | 1 | 1% |
Colombia | 1 | 1% |
Germany | 1 | 1% |
Malaysia | 1 | 1% |
India | 1 | 1% |
Unknown | 88 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 17 | 18% |
Student > Master | 14 | 15% |
Student > Bachelor | 8 | 9% |
Other | 6 | 6% |
Researcher | 6 | 6% |
Other | 19 | 20% |
Unknown | 23 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 16 | 17% |
Pharmacology, Toxicology and Pharmaceutical Science | 13 | 14% |
Medicine and Dentistry | 9 | 10% |
Biochemistry, Genetics and Molecular Biology | 7 | 8% |
Chemistry | 7 | 8% |
Other | 14 | 15% |
Unknown | 27 | 29% |