| Title |
Identifying craniofacial features associated with prenatal exposure to androgens and testing their relationship with brain development
|
|---|---|
| Published in |
Brain Structure and Function, July 2014
|
| DOI | 10.1007/s00429-014-0852-3 |
| Pubmed ID | |
| Authors |
Klára Marečková, Mallar M. Chakravarty, Claire Lawrence, Gabriel Leonard, Daniel Perusse, Michel Perron, Bruce G. Pike, Louis Richer, Suzanne Veillette, Zdenka Pausova, Tomáš Paus |
| Abstract |
We used magnetic resonance (MR) images obtained in same-sex and opposite-sex dizygotic twins (n = 119, 8 years of age) to study possible effects of prenatal androgens on craniofacial features. Using a principal component analysis of 19 craniofacial landmarks placed on the MR images, we identified a principal component capturing craniofacial features that distinguished females with a presumed differential exposure to prenatal androgens by virtue of having a male (vs. a female) co-twin (Cohen's d = 0.76). Subsequently, we tested the possibility that this craniofacial "signature" of prenatal exposure to androgens predicts brain size, a known sexually dimorphic trait. In an independent sample of female adolescents (singletons; n = 462), we found that the facial signature predicts up to 8 % of variance in brain size. These findings are consistent with the organizational effects of androgens on brain development and suggest that the facial signature derived in this study could complement other indirect measures of prenatal exposure to androgens. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 41 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 6 | 15% |
| Researcher | 4 | 10% |
| Student > Postgraduate | 4 | 10% |
| Other | 3 | 7% |
| Student > Master | 3 | 7% |
| Other | 9 | 22% |
| Unknown | 12 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 6 | 15% |
| Agricultural and Biological Sciences | 6 | 15% |
| Psychology | 6 | 15% |
| Neuroscience | 3 | 7% |
| Social Sciences | 2 | 5% |
| Other | 4 | 10% |
| Unknown | 14 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 August 2014.
All research outputs
#21,697,638
of 24,217,893 outputs
Outputs from Brain Structure and Function
#1,524
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Outputs of similar age
#199,490
of 233,139 outputs
Outputs of similar age from Brain Structure and Function
#34
of 40 outputs
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