| Title |
Functions of Chondroitin Sulfate and Heparan Sulfate in the Developing Brain
|
|---|---|
| Published in |
Neurochemical Research, November 2010
|
| DOI | 10.1007/s11064-010-0324-y |
| Pubmed ID | |
| Authors |
N. Maeda, M. Ishii, K. Nishimura, K. Kamimura |
| Abstract |
Chondroitin sulfate and heparan sulfate proteoglycans are major components of the cell surface and extracellular matrix in the brain. Both chondroitin sulfate and heparan sulfate are unbranched highly sulfated polysaccharides composed of repeating disaccharide units of glucuronic acid and N-acetylgalactosamine, and glucuronic acid and N-acetylglucosamine, respectively. During their biosynthesis in the Golgi apparatus, these glycosaminoglycans are highly modified by sulfation and C5 epimerization of glucuronic acid, leading to diverse heterogeneity in structure. Their structures are strictly regulated in a cell type-specific manner during development partly by the expression control of various glycosaminoglycan-modifying enzymes. It has been considered that specific combinations of glycosaminoglycan-modifying enzymes generate specific functional microdomains in the glycosaminoglycan chains, which bind selectively with various growth factors, morphogens, axon guidance molecules and extracellular matrix proteins. Recent studies have begun to reveal that the molecular interactions mediated by such glycosaminoglycan microdomains play critical roles in the various signaling pathways essential for the development of the brain. |
Mendeley readers
The data shown below were compiled from readership statistics for 127 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Finland | 1 | <1% |
| United States | 1 | <1% |
| Sweden | 1 | <1% |
| Unknown | 124 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 30 | 24% |
| Student > Master | 15 | 12% |
| Student > Bachelor | 15 | 12% |
| Researcher | 14 | 11% |
| Student > Postgraduate | 7 | 6% |
| Other | 18 | 14% |
| Unknown | 28 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 32 | 25% |
| Biochemistry, Genetics and Molecular Biology | 21 | 17% |
| Medicine and Dentistry | 12 | 9% |
| Neuroscience | 12 | 9% |
| Chemistry | 10 | 8% |
| Other | 11 | 9% |
| Unknown | 29 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 August 2014.
All research outputs
#20,233,547
of 22,759,618 outputs
Outputs from Neurochemical Research
#1,686
of 2,089 outputs
Outputs of similar age
#170,145
of 180,420 outputs
Outputs of similar age from Neurochemical Research
#20
of 22 outputs
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