| Title |
Hypolipidemic Effect of Avocado (Persea americana Mill) Seed in a Hypercholesterolemic Mouse Model
|
|---|---|
| Published in |
Plant Foods for Human Nutrition, March 2012
|
| DOI | 10.1007/s11130-012-0280-6 |
| Pubmed ID | |
| Authors |
María Elena Pahua-Ramos, Alicia Ortiz-Moreno, Germán Chamorro-Cevallos, María Dolores Hernández-Navarro, Leticia Garduño-Siciliano, Hugo Necoechea-Mondragón, Marcela Hernández-Ortega |
| Abstract |
Avocado seed contains elevated levels of phenolic compounds and exhibits antioxidant properties. We investigated the effect of Avocado Seed Flour (ASF) on the lipid levels in mice on a hyperlipidemic diet. The concentration of phenols was determined by high-performance liquid chromatography, antioxidant activity was evaluated using the Trolox equivalent antioxidant capacity method, and dietary fiber was measured using the Association of Official Analytical Chemists (AOAC) method. The LD50 of ASF was determined using Lorke's method and hypolipidemic activity was evaluated in a hypercholesterolemic model in mice. Protocatechuic acid was the main phenolic compound found in ASF, followed by kaempferide and vanillic acid. The total phenolic content in the methanolic extract of ASF was 292.00 ± 9.81 mg gallic acid equivalents/g seed dry weight and the antioxidant activity resulted in 173.3 μmol Trolox equivalents/g DW. In addition, a high content of dietary fiber was found (34.8%). The oral LD50 for ASF was 1767 mg/kg body weight, and treatment with ASF significantly reduced the levels of total cholesterol, LDL-C, and prediction of the atherogenic index. Therefore, the antioxidant activity of phenolic compounds and dietary fiber in ASF may be responsible for the hypocholesterolemic activity of ASF in a hyperlipidemic model of mice. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 1 | 20% |
| Venezuela, Bolivarian Republic of | 1 | 20% |
| Unknown | 3 | 60% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 211 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | <1% |
| Mexico | 1 | <1% |
| Ghana | 1 | <1% |
| South Africa | 1 | <1% |
| Unknown | 206 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 41 | 19% |
| Student > Bachelor | 34 | 16% |
| Student > Ph. D. Student | 22 | 10% |
| Student > Doctoral Student | 16 | 8% |
| Researcher | 13 | 6% |
| Other | 29 | 14% |
| Unknown | 56 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 45 | 21% |
| Chemistry | 24 | 11% |
| Biochemistry, Genetics and Molecular Biology | 17 | 8% |
| Engineering | 17 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 15 | 7% |
| Other | 26 | 12% |
| Unknown | 67 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 October 2023.
All research outputs
#6,305,484
of 24,709,170 outputs
Outputs from Plant Foods for Human Nutrition
#235
of 736 outputs
Outputs of similar age
#39,349
of 160,129 outputs
Outputs of similar age from Plant Foods for Human Nutrition
#5
of 7 outputs
Altmetric has tracked 24,709,170 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 736 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.9. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 160,129 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.