| Title |
Ageing and osteoarthritis: a circadian rhythm connection
|
|---|---|
| Published in |
Biogerontology, July 2014
|
| DOI | 10.1007/s10522-014-9522-3 |
| Pubmed ID | |
| Authors |
Nicole Gossan, Ray Boot-Handford, Qing-Jun Meng |
| Abstract |
Osteoarthritis (OA) is the most common joint disease, affecting articular cartilage of the joints, with currently no cure. Age is a major risk factor for OA, but despite significant advances made in the OA research field, how ageing contributes to OA is still not well understood. In this review, we will focus on one particular aspect of chondrocyte biology, i.e., circadian rhythms. Disruptions to circadian clocks have been linked to various diseases. Our recent work demonstrates autonomous clocks in chondrocytes which regulate key pathways implicated in OA. The cartilage rhythm dampens with age and clock gene expression changes during the initiation stage of OA development in an experimental mouse OA model. Research into the molecular links between ageing, circadian clocks and OA may identify novel therapeutic routes for the prevention and management of OA, such as chronotherapy, or direct targeting of clock components/circadian rhythm. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 50% |
| United States | 1 | 25% |
| Unknown | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 2 | 50% |
| Members of the public | 1 | 25% |
| Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 78 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 1% |
| Unknown | 77 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 18% |
| Student > Bachelor | 11 | 14% |
| Researcher | 10 | 13% |
| Student > Master | 10 | 13% |
| Student > Postgraduate | 7 | 9% |
| Other | 13 | 17% |
| Unknown | 13 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 20 | 26% |
| Medicine and Dentistry | 19 | 24% |
| Agricultural and Biological Sciences | 11 | 14% |
| Engineering | 4 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 4% |
| Other | 7 | 9% |
| Unknown | 14 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 August 2017.
All research outputs
#8,074,121
of 25,670,640 outputs
Outputs from Biogerontology
#288
of 728 outputs
Outputs of similar age
#71,436
of 239,829 outputs
Outputs of similar age from Biogerontology
#6
of 16 outputs
Altmetric has tracked 25,670,640 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 728 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 239,829 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.