| Title |
Proliferation and migration of tumor cells in tapered channels
|
|---|---|
| Published in |
Biomedical Microdevices, October 2012
|
| DOI | 10.1007/s10544-012-9721-0 |
| Pubmed ID | |
| Authors |
Yuan Wan, Deepika Tamuly, Peter B. Allen, Young-tae Kim, Robert Bachoo, Andrew D. Ellington, Samir M. Iqbal |
| Abstract |
Tumor cells depict two deviant tendencies; over-proliferation and vigorous migration. A tapered channel device is designed and fabricated for in vitro studies. We report inhibited proliferation and migration of human glioblastoma (hGBM) cells when exposed to an aptamer that is known to bind epidermal growth factor receptors (EGFR). The device is integrated with controlled ambient and microscope for providing real-time and quantitative characterization of the tumor cell behavior. The results show that hGBM cells loose proliferation and motility when exposed to the anti-EGFR aptamer. The aptamer directly inhibits and blocks EGF-induced EGFR phosphorylation. This also reduces the ability of cells to remodel their internal structure for invasion through narrow constrictions. This provides a framework for possible studies on efficacy of other inhibiting molecules. |
Mendeley readers
The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| China | 1 | 3% |
| Unknown | 37 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 15 | 39% |
| Student > Ph. D. Student | 7 | 18% |
| Other | 4 | 11% |
| Student > Master | 2 | 5% |
| Student > Bachelor | 1 | 3% |
| Other | 4 | 11% |
| Unknown | 5 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 14 | 37% |
| Biochemistry, Genetics and Molecular Biology | 6 | 16% |
| Engineering | 4 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 5% |
| Medicine and Dentistry | 2 | 5% |
| Other | 4 | 11% |
| Unknown | 6 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 August 2014.
All research outputs
#20,233,547
of 22,759,618 outputs
Outputs from Biomedical Microdevices
#665
of 746 outputs
Outputs of similar age
#163,379
of 183,421 outputs
Outputs of similar age from Biomedical Microdevices
#9
of 9 outputs
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So far Altmetric has tracked 746 research outputs from this source. They receive a mean Attention Score of 4.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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