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Comparison of gene expression microarray data with count-based RNA measurements informs microarray interpretation

Overview of attention for article published in BMC Genomics, August 2014
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Title
Comparison of gene expression microarray data with count-based RNA measurements informs microarray interpretation
Published in
BMC Genomics, August 2014
DOI 10.1186/1471-2164-15-649
Pubmed ID
Authors

Arianne C Richard, Paul A Lyons, James E Peters, Daniele Biasci, Shaun M Flint, James C Lee, Eoin F McKinney, Richard M Siegel, Kenneth GC Smith

Abstract

Although numerous investigations have compared gene expression microarray platforms, preprocessing methods and batch correction algorithms using constructed spike-in or dilution datasets, there remains a paucity of studies examining the properties of microarray data using diverse biological samples. Most microarray experiments seek to identify subtle differences between samples with variable background noise, a scenario poorly represented by constructed datasets. Thus, microarray users lack important information regarding the complexities introduced in real-world experimental settings. The recent development of a multiplexed, digital technology for nucleic acid measurement enables counting of individual RNA molecules without amplification and, for the first time, permits such a study.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 106 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 4 4%
United Kingdom 3 3%
Hong Kong 1 <1%
Netherlands 1 <1%
Finland 1 <1%
Unknown 96 91%

Demographic breakdown

Readers by professional status Count As %
Researcher 29 27%
Student > Ph. D. Student 18 17%
Student > Bachelor 16 15%
Student > Master 13 12%
Other 5 5%
Other 19 18%
Unknown 6 6%
Readers by discipline Count As %
Agricultural and Biological Sciences 45 42%
Biochemistry, Genetics and Molecular Biology 19 18%
Medicine and Dentistry 15 14%
Computer Science 4 4%
Mathematics 3 3%
Other 8 8%
Unknown 12 11%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 August 2014.
All research outputs
#18,801,532
of 23,301,510 outputs
Outputs from BMC Genomics
#8,246
of 10,742 outputs
Outputs of similar age
#165,617
of 231,188 outputs
Outputs of similar age from BMC Genomics
#124
of 189 outputs
Altmetric has tracked 23,301,510 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 10,742 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
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