| Title |
Bisphenol-A Impairs Myelination Potential During Development in the Hippocampus of the Rat Brain
|
|---|---|
| Published in |
Molecular Neurobiology, August 2014
|
| DOI | 10.1007/s12035-014-8817-3 |
| Pubmed ID | |
| Authors |
Shashi Kant Tiwari, Swati Agarwal, Lalit Kumar Singh Chauhan, Vijay Nath Mishra, Rajnish Kumar Chaturvedi |
| Abstract |
Myelin is the functional implication of oligodendrocytes (OLs), which is involved in insulation of axons and promoting rapid propagation of action potential in the brain. OLs are derived from oligodendrocyte progenitor cells (OPCs), which proliferate, differentiate, and migrate throughout the central nervous system. Defects in myelination process lead to the onset of several neurological and neurodegenerative disorders. Exposure to synthetic xenoestrogen bisphenol-A (BPA) causes cognitive dysfunction, impairs hippocampal neurogenesis, and causes onset of neurodevelopmental disorders. However, the effects of BPA on OPC proliferation, differentiation and myelination, and associated cellular and molecular mechanism(s) in the hippocampus of the rat brain are still largely unknown. We found that BPA significantly decreased bromodeoxyuridine (BrdU)-positive cell proliferation and number and size of oligospheres. We observed reduced co-localization of BrdU with myelination markers CNPase and platelet-derived growth factor receptor-α (PDGFR-α), suggesting impaired proliferation and differentiation of OPCs by BPA in culture. We studied the effects of BPA exposure during prenatal and postnatal periods on cellular and molecular alteration(s) in the myelination process in the hippocampus region of the rat brain at postnatal day 21 and 90. BPA exposure both in vitro and in vivo altered proliferation and differentiation potential of OPCs and decreased the expression of genes and levels of proteins that are involved in myelination. Ultrastructural electron microscopy analysis revealed that BPA exposure caused decompaction of myelinated axons and altered g-ratio at both the developmental periods as compared to control. These results suggest that BPA exposure both during prenatal and postnatal periods alters myelination in the hippocampus of the rat brain leading to cognitive deficits. |
Mendeley readers
The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 62 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 19% |
| Student > Master | 10 | 16% |
| Student > Bachelor | 8 | 13% |
| Student > Doctoral Student | 6 | 10% |
| Researcher | 6 | 10% |
| Other | 6 | 10% |
| Unknown | 14 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 11 | 18% |
| Biochemistry, Genetics and Molecular Biology | 8 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 11% |
| Agricultural and Biological Sciences | 6 | 10% |
| Medicine and Dentistry | 3 | 5% |
| Other | 8 | 13% |
| Unknown | 19 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 August 2014.
All research outputs
#20,233,547
of 22,759,618 outputs
Outputs from Molecular Neurobiology
#2,777
of 3,436 outputs
Outputs of similar age
#193,351
of 229,696 outputs
Outputs of similar age from Molecular Neurobiology
#30
of 40 outputs
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