| Title |
Glutamate NMDAR1 receptors localised to nerves in human Achilles tendons. Implications for treatment?
|
|---|---|
| Published in |
Knee Surgery, Sports Traumatology, Arthroscopy, February 2001
|
| DOI | 10.1007/s001670000188 |
| Pubmed ID | |
| Authors |
Håkan Alfredson, Sture Forsgren, Kim Thorsen, Martin Fahlström, Håkan Johansson, Ronny Lorentzon |
| Abstract |
In this investigation, we show the presence of both free glutamate (microdialysis) and glutamate NMDAR1 receptors (immunohistochemical analyses of tendon biopsies), in tendons from patients with chronic Achilles tendon pain (Achilles tendinosis) and in controls (pain-free tendons). The NMDAR1 immunoreaction was usually confined to acetylcholinesterase-positive structures, implying that the reaction is present in nerves. Glutamate is a potent pain mediator in the human central nervous system, and in animals it has been shown that peripherally administered glutamate NMDA receptor antagonists diminish the response to formalin-induced nociception. Our present finding of glutamate NMDA receptors in human Achilles tendons might have implications for pain treatment. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | 2% |
| Norway | 1 | 2% |
| Unknown | 46 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 25% |
| Student > Master | 7 | 15% |
| Student > Bachelor | 6 | 13% |
| Other | 4 | 8% |
| Researcher | 4 | 8% |
| Other | 6 | 13% |
| Unknown | 9 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 16 | 33% |
| Sports and Recreations | 7 | 15% |
| Agricultural and Biological Sciences | 3 | 6% |
| Nursing and Health Professions | 2 | 4% |
| Chemistry | 2 | 4% |
| Other | 5 | 10% |
| Unknown | 13 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 August 2014.
All research outputs
#18,375,478
of 22,759,618 outputs
Outputs from Knee Surgery, Sports Traumatology, Arthroscopy
#2,095
of 2,642 outputs
Outputs of similar age
#37,796
of 39,598 outputs
Outputs of similar age from Knee Surgery, Sports Traumatology, Arthroscopy
#4
of 4 outputs
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So far Altmetric has tracked 2,642 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one is in the 8th percentile – i.e., 8% of its peers scored the same or lower than it.
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