| Title |
Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia
|
|---|---|
| Published in |
European Archives of Psychiatry and Clinical Neuroscience, January 2009
|
| DOI | 10.1007/s00406-008-0847-2 |
| Pubmed ID | |
| Authors |
Daniel Martins-de-Souza, Wagner F. Gattaz, Andrea Schmitt, Christiane Rewerts, Giuseppina Maccarrone, Emmanuel Dias-Neto, Christoph W. Turck |
| Abstract |
Schizophrenia is a complex disease, likely to be caused by a combination of serial alterations in a number of genes and environmental factors. The dorsolateral prefrontal cortex (Brodmann's Area 46) is involved in schizophrenia and executes high-level functions such as working memory, differentiation of conflicting thoughts, determination of right and wrong concepts and attitudes, correct social behavior and personality expression. Global proteomic analysis of post-mortem dorsolateral prefrontal cortex samples from schizophrenia patients and non-schizophrenic individuals was performed using stable isotope labeling and shotgun proteomics. The analysis resulted in the identification of 1,261 proteins, 84 of which showed statistically significant differential expression, reinforcing previous data supporting the involvement of the immune system, calcium homeostasis, cytoskeleton assembly, and energy metabolism in schizophrenia. In addition a number of new potential markers were found that may contribute to the understanding of the pathogenesis of this complex disease. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 150 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 2% |
| Brazil | 2 | 1% |
| Italy | 2 | 1% |
| United Kingdom | 2 | 1% |
| Japan | 1 | <1% |
| Unknown | 140 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 35 | 23% |
| Researcher | 24 | 16% |
| Student > Master | 14 | 9% |
| Student > Bachelor | 14 | 9% |
| Professor | 8 | 5% |
| Other | 30 | 20% |
| Unknown | 25 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 59 | 39% |
| Neuroscience | 23 | 15% |
| Biochemistry, Genetics and Molecular Biology | 14 | 9% |
| Medicine and Dentistry | 14 | 9% |
| Psychology | 4 | 3% |
| Other | 10 | 7% |
| Unknown | 26 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 October 2018.
All research outputs
#7,325,024
of 23,815,455 outputs
Outputs from European Archives of Psychiatry and Clinical Neuroscience
#421
of 1,243 outputs
Outputs of similar age
#48,228
of 175,197 outputs
Outputs of similar age from European Archives of Psychiatry and Clinical Neuroscience
#3
of 7 outputs
Altmetric has tracked 23,815,455 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 1,243 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 175,197 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.