Title |
Biomechanical considerations in the pathogenesis of osteoarthritis of the knee
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Published in |
Knee Surgery, Sports Traumatology, Arthroscopy, December 2011
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DOI | 10.1007/s00167-011-1818-0 |
Pubmed ID | |
Authors |
Andras Heijink, Andreas H. Gomoll, Henning Madry, Matej Drobnič, Giuseppe Filardo, João Espregueira‐Mendes, C. Niek Van Dijk |
Abstract |
Osteoarthritis is the most common joint disease and a major cause of disability. The knee is the large joint most affected. While chronological age is the single most important risk factor of osteoarthritis, the pathogenesis of knee osteoarthritis in the young patient is predominantly related to an unfavorable biomechanical environment at the joint. This results in mechanical demand that exceeds the ability of a joint to repair and maintain itself, predisposing the articular cartilage to premature degeneration. This review examines the available basic science, preclinical and clinical evidence regarding several such unfavorable biomechanical conditions about the knee: malalignment, loss of meniscal tissue, cartilage defects and joint instability or laxity. Level of evidence IV. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
United Kingdom | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 2 | <1% |
Germany | 1 | <1% |
Netherlands | 1 | <1% |
Ireland | 1 | <1% |
Portugal | 1 | <1% |
Brazil | 1 | <1% |
Australia | 1 | <1% |
Mexico | 1 | <1% |
Sweden | 1 | <1% |
Other | 0 | 0% |
Unknown | 457 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 79 | 17% |
Student > Ph. D. Student | 70 | 15% |
Student > Bachelor | 67 | 14% |
Researcher | 47 | 10% |
Student > Doctoral Student | 30 | 6% |
Other | 94 | 20% |
Unknown | 80 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 163 | 35% |
Engineering | 58 | 12% |
Agricultural and Biological Sciences | 33 | 7% |
Nursing and Health Professions | 29 | 6% |
Biochemistry, Genetics and Molecular Biology | 21 | 4% |
Other | 58 | 12% |
Unknown | 105 | 22% |