Title |
Systematic reviews of adverse effects: framework for a structured approach
|
---|---|
Published in |
BMC Medical Research Methodology, July 2007
|
DOI | 10.1186/1471-2288-7-32 |
Pubmed ID | |
Authors |
Yoon K Loke, Deirdre Price, Andrew Herxheimer, the Cochrane Adverse Effects Methods Group |
Abstract |
As every healthcare intervention carries some risk of harm, clinical decision making needs to be supported by a systematic assessment of the balance of benefit to harm. A systematic review that considers only the favourable outcomes of an intervention, without also assessing the adverse effects, can mislead by introducing a bias favouring the intervention. Much of the current guidance on systematic reviews is directed towards the evaluation of effectiveness; but this differs in important ways from the methods used in assessing the safety and tolerability of an intervention. A detailed discussion of why, how and when to include adverse effects in a systematic review, is required. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Canada | 1 | 50% |
United States | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 6 | 2% |
United Kingdom | 5 | 2% |
Brazil | 2 | <1% |
Canada | 2 | <1% |
Spain | 1 | <1% |
Colombia | 1 | <1% |
Unknown | 228 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 45 | 18% |
Student > Ph. D. Student | 33 | 13% |
Student > Master | 32 | 13% |
Student > Postgraduate | 15 | 6% |
Other | 14 | 6% |
Other | 71 | 29% |
Unknown | 35 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 102 | 42% |
Nursing and Health Professions | 19 | 8% |
Social Sciences | 16 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 11 | 4% |
Agricultural and Biological Sciences | 8 | 3% |
Other | 39 | 16% |
Unknown | 50 | 20% |