| Title |
Resistance of Candida spp. to antifungal drugs in the ICU: where are we now?
|
|---|---|
| Published in |
Intensive Care Medicine, August 2014
|
| DOI | 10.1007/s00134-014-3404-7 |
| Pubmed ID | |
| Authors |
Danièle Maubon, Cécile Garnaud, Thierry Calandra, Dominique Sanglard, Muriel Cornet |
| Abstract |
Current increases in antifungal drug resistance in Candida spp. and clinical treatment failures are of concern, as invasive candidiasis is a significant cause of mortality in intensive care units (ICUs). This trend reflects the large and expanding use of newer broad-spectrum antifungal agents, such as triazoles and echinocandins. In this review, we firstly present an overview of the mechanisms of action of the drugs and of resistance in pathogenic yeasts, subsequently focusing on recent changes in the epidemiology of antifungal resistance in ICU. Then, we emphasize the clinical impacts of these current trends. The emergence of clinical treatment failures due to resistant isolates is described. We also consider the clinical usefulness of recent advances in the interpretation of antifungal susceptibility testing and in molecular detection of the mutations underlying acquired resistance. We pay particular attention to practical issues relating to ICU patient management, taking into account the growing threat of antifungal drug resistance. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 50% |
| France | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 170 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | <1% |
| Czechia | 1 | <1% |
| Canada | 1 | <1% |
| Denmark | 1 | <1% |
| Poland | 1 | <1% |
| Unknown | 165 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 26 | 15% |
| Student > Ph. D. Student | 24 | 14% |
| Researcher | 18 | 11% |
| Student > Bachelor | 18 | 11% |
| Student > Doctoral Student | 13 | 8% |
| Other | 34 | 20% |
| Unknown | 37 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 41 | 24% |
| Immunology and Microbiology | 23 | 14% |
| Biochemistry, Genetics and Molecular Biology | 21 | 12% |
| Agricultural and Biological Sciences | 20 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 5% |
| Other | 13 | 8% |
| Unknown | 43 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 August 2022.
All research outputs
#6,382,652
of 23,103,436 outputs
Outputs from Intensive Care Medicine
#2,625
of 5,031 outputs
Outputs of similar age
#60,056
of 230,983 outputs
Outputs of similar age from Intensive Care Medicine
#17
of 51 outputs
Altmetric has tracked 23,103,436 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 5,031 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 230,983 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 51 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.