Title |
Disruption of vascular homeostasis in patients with Kawasaki disease: Involvement of vascular endothelial growth factor and angiopoietins
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Published in |
Arthritis & Rheumatism, December 2011
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DOI | 10.1002/art.33316 |
Pubmed ID | |
Authors |
Willemijn B. Breunis, Sonia Davila, Chisato Shimizu, Toshiaki Oharaseki, Kei Takahashi, Michel van Houdt, Chiea Chuen Khor, Victoria J. Wright, Michael Levin, Jane C. Burns, David Burgner, Martin L. Hibberd, Taco W. Kuijpers, International Kawasaki Disease Genetics Consortium |
Abstract |
In Kawasaki disease (KD), a pediatric vasculitis of medium-sized arteries, the coronary arteries are most commonly affected. Angiopoietins and vascular endothelial growth factor (VEGF) play an important role in maintaining vascular homeostasis. Recently, we identified ANGPT1 and VEGFA as susceptibility loci for KD. This study was undertaken to fine-map these associations and to gain further insight into their role in this vasculitis of unknown etiology to further the search for improved diagnostic and therapeutic options. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 2% |
Finland | 1 | 2% |
United States | 1 | 2% |
Unknown | 39 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 9 | 21% |
Student > Master | 8 | 19% |
Other | 5 | 12% |
Student > Ph. D. Student | 4 | 10% |
Professor > Associate Professor | 3 | 7% |
Other | 9 | 21% |
Unknown | 4 | 10% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 20 | 48% |
Agricultural and Biological Sciences | 5 | 12% |
Biochemistry, Genetics and Molecular Biology | 2 | 5% |
Nursing and Health Professions | 2 | 5% |
Computer Science | 1 | 2% |
Other | 2 | 5% |
Unknown | 10 | 24% |