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Association of Aortic Root Dilation from Early Adulthood to Middle Age with Cardiac Structure and Function: The CARDIA Study

Overview of attention for article published in Journal of the American Society of Echocardiography (Online), September 2017
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Title
Association of Aortic Root Dilation from Early Adulthood to Middle Age with Cardiac Structure and Function: The CARDIA Study
Published in
Journal of the American Society of Echocardiography (Online), September 2017
DOI 10.1016/j.echo.2017.08.001
Pubmed ID
Authors

Chike C. Nwabuo, Henrique T. Moreira, Henrique D. Vasconcellos, Bharath Ambale-Venkatesh, Kihei Yoneyama, Yoshiaki Ohyama, Ravi K. Sharma, Anderson C. Armstrong, Mohammed R. Ostovaneh, Cora E. Lewis, Kiang Liu, Pamela J. Schreiner, Kofo O. Ogunyankin, Samuel S. Gidding, João A.C. Lima

Abstract

The human aorta dilates with advancing age. However, the association between progressive aortic dilation with aging and cardiac remodeling has not been established in studies of community-dwelling adults. The aim of this study was to test the hypothesis that there would be a relationship between aortic size increase over the early adult life span with left ventricular (LV) structural remodeling and subclinical LV dysfunction in middle age, even in the absence of overt cardiovascular and valvular disease. Included were Coronary Artery Risk Development in Young Adults study participants (N = 2,933) aged 23 to 35 years with available transthoracic echocardiographic measurements during 20 years of follow-up. Multivariate linear regression models assessed sex-specific associations between 20-year change in aortic root diameter with LV structure and function. Larger aortic root diameter at 20-year follow-up was associated with greater LV mass (2.77 vs 2.18 g/mm in men and women, respectively, P < .001). In longitudinal analyses, increase in aortic root diameter over 20-year follow-up was associated with a greater 20-year increase in LV mass and ratio of LV mass to LV end-diastolic volume ratio in both sexes. In women but not in men, increased aortic root diameter over 20 years was associated with increased left atrial dimension, impaired E/E', and impaired early diastolic longitudinal and circumferential strain rates assessed by speckle-tracking echocardiography. Progressive increase in aortic root diameter from early adulthood to middle age was associated with increased LV mass and LV concentric remodeling in both sexes and impaired diastolic function predominantly in women.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 37 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 19%
Other 5 14%
Student > Bachelor 5 14%
Researcher 5 14%
Student > Doctoral Student 3 8%
Other 4 11%
Unknown 8 22%
Readers by discipline Count As %
Medicine and Dentistry 15 41%
Engineering 3 8%
Psychology 2 5%
Nursing and Health Professions 2 5%
Sports and Recreations 1 3%
Other 3 8%
Unknown 11 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 September 2017.
All research outputs
#14,864,670
of 25,498,750 outputs
Outputs from Journal of the American Society of Echocardiography (Online)
#1,301
of 1,942 outputs
Outputs of similar age
#161,993
of 323,668 outputs
Outputs of similar age from Journal of the American Society of Echocardiography (Online)
#20
of 31 outputs
Altmetric has tracked 25,498,750 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,942 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.7. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 323,668 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.