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Attention Score in Context
| Title |
Zinc oxide nanoparticles: Genotoxicity, interactions with UV-light and cell-transforming potential
|
|---|---|
| Published in |
Journal of Hazardous Materials, November 2013
|
| DOI | 10.1016/j.jhazmat.2013.11.043 |
| Pubmed ID | |
| Authors |
Eşref Demir, Hakan Akça, Bülent Kaya, Durmuş Burgucu, Onur Tokgün, Fatma Turna, Sezgin Aksakal, Gerard Vales, Amadeu Creus, Ricard Marcos |
| Abstract |
The in vitro genotoxic and the soft agar anchorage independent cell transformation ability of zinc oxide nanoparticles (NPs) and its bulky forms have been evaluated in human embryonic kidney (HEK293) and in mouse embryonic fibroblast (NIH/3T3) cells, either alone or in combination with UVB-light. The comet assay, with and without the use of FPG and Endo III enzymes, the micronucleus assay and the soft-agar colony assay were used. For the comet assay a statistically significant induction of DNA damage, with and without the enzymes, were observed up of 100μg/mL. ZnO NPs were able to increase significantly the frequency of micronuclei, and similar results were observed in the cell transformation assay where such NPs were able to induce cell-anchorage independent growth. These effects were observed at doses up 100μg/mL. Although UVB-light was able to induce genotoxic damage and cell-anchorage growth, a significant antagonist interaction effect was observed in combination with ZnO NPs. These in vitro results, obtained with the selected cell lines, contribute to increase our genotoxicity database on the ZnO NPs effects as well as to open the discussion about their risk in photo-protection sun screens. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 79 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 1% |
| Unknown | 78 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 22 | 28% |
| Student > Master | 11 | 14% |
| Student > Bachelor | 10 | 13% |
| Researcher | 6 | 8% |
| Student > Doctoral Student | 4 | 5% |
| Other | 13 | 16% |
| Unknown | 13 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 24 | 30% |
| Biochemistry, Genetics and Molecular Biology | 10 | 13% |
| Chemistry | 6 | 8% |
| Medicine and Dentistry | 4 | 5% |
| Environmental Science | 4 | 5% |
| Other | 14 | 18% |
| Unknown | 17 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 August 2014.
All research outputs
#20,656,820
of 25,374,647 outputs
Outputs from Journal of Hazardous Materials
#5,170
of 7,087 outputs
Outputs of similar age
#243,125
of 317,659 outputs
Outputs of similar age from Journal of Hazardous Materials
#24
of 46 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,087 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 317,659 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.