Title |
Working towards a Group A Streptococcal vaccine: Report of a collaborative Trans-Tasman workshop
|
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Published in |
Vaccine, May 2014
|
DOI | 10.1016/j.vaccine.2014.05.017 |
Pubmed ID | |
Authors |
Nicole J. Moreland, Claire S. Waddington, Deborah A. Williamson, Shiranee Sriskandan, Pierre R. Smeesters, Thomas Proft, Andrew C. Steer, Mark J. Walker, Edward N. Baker, Michael G. Baker, Diana Lennon, Rod Dunbar, Jonathan Carapetis, John D. Fraser |
Abstract |
Group A Streptococcus (GAS) infections represent a major public health burden in both developing and developed countries. In Australia and New Zealand GAS associated diseases are serious problems in Indigenous populations and a major cause of health inequality. Political recognition of these inequalities is providing impetus for strategies that reduce GAS disease and the development of a GAS vaccine now has governmental support in both Australia and New Zealand. Accordingly, an expert workshop was convened in March 2013 to consider available data on GAS vaccines. M-protein based vaccines constructed from the hyper-variable N-terminal region (30-valent vaccine) or the conserved C-repeat domain (J8 vaccine) were reviewed together with vaccine candidates identified using multi high-throughput approaches. Performing a comprehensive assessment of regional GAS strain epidemiology, defining the immune correlates of protection, and the establishment of clinical trial sites were identified as critical activities for a Trans-Tasman vaccine development programme. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Switzerland | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 2 | 3% |
Brazil | 1 | 2% |
Unknown | 57 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 11 | 18% |
Student > Ph. D. Student | 10 | 17% |
Student > Bachelor | 9 | 15% |
Student > Master | 7 | 12% |
Student > Doctoral Student | 4 | 7% |
Other | 8 | 13% |
Unknown | 11 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 17 | 28% |
Agricultural and Biological Sciences | 11 | 18% |
Immunology and Microbiology | 4 | 7% |
Social Sciences | 3 | 5% |
Biochemistry, Genetics and Molecular Biology | 3 | 5% |
Other | 8 | 13% |
Unknown | 14 | 23% |